Effects of Hint1 deficiency on emotional-like behaviors in mice under chronic immobilization stress

Brain and Behavior
Liankang SunYong-hui Dang

Abstract

Histidine triad nucleotide-binding protein 1 (HINT1) is regarded as a haplo-insufficient tumor suppressor and is closely associated with diverse neuropsychiatric diseases. Moreover, HINT1 is related to gender-specific acute behavior changes in schizophrenia and in response to nicotine. Stress has a range of molecular effects in emotional disorders, which can cause a reduction in brain-derived neurotrophic factor (BDNF) expression in the hippocampus, resulting in hippocampal atrophy and neuronal cell loss. This study examined the role of HINT1 deficiency in anxiety-related and depression-like behaviors and BDNF expression in the hippocampus under chronic immobilization stress, and investigated whether the sex-specific and haplo-insufficient effects exist in emotional-like behaviors under the same condition. In a battery of behavior tests, the results of the control group, not exposed to stress, showed that knockout (KO) and heterozygosity (HT) of Hint1 had anxiolytic-like and antidepression-like effects on the male and female mice. However, both male and female Hint1-KO mice showed elevated anxiety-related and antidepression-like behavior under chronic immobilization stress; moreover, both male and female Hint1-HT mice displayed...Continue Reading

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Citations

Mar 17, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yajing HouJiaxu Chen
Dec 8, 2017·Neural Plasticity·Peng LiuYonghui Dang
Feb 28, 2019·Frontiers in Molecular Neuroscience·Chuanjun ZhuoLi Zhang

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Methods Mentioned

BETA
PCR
protein assay

Software Mentioned

Quantity One
SPSS18
QuantityOne
SMART

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