Effects of hippocampal lesions on spatial delayed responses in dog

Hippocampus
D M Kowalska

Abstract

Thirteen dogs were trained to perform spatial delayed responses to auditory cues in a three-choice Nencki testing apparatus with a delay of 0 s and then 10 s with a criterion of 90% correct responses in 90 consecutive trials. Then six dogs received bilateral surgical removal of the hippocampus via the cortex of the suprasylvian gyrus (without additional injury to the entorhinal and parahippocampal cortex). Three dogs received control surgical ablation of the suprasylvian gyrus, which was damaged in ablation of the hippocampus, and four dogs served as intact controls. After the surgery or rest period, the dogs were tested for their retention (10-s delay), and then they were given additional tests with extended delays (30, 60, and 120 s) and with distractions during the 60-s delay period. In comparison with both control groups, dogs with hippocampal ablations had moderately impaired postoperative retention, as evidenced by the elevated numbers of errors on criterion. In subsequent stages of testing with extended delays, the impairment was greater and was significantly correlated with the extent of injury to the hippocampus. These data, together with an analysis of the animals' responses to the three-choice situation, indicate tha...Continue Reading

References

Apr 1, 1988·Trends in Neurosciences·L R Squire, S Zola-Morgan
Feb 13, 1985·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R E Passingham
Jan 1, 1989·Experimental Brain Research·D Gaffan, S Harrison
May 1, 1970·Experimental Neurology·P S Goldman, H E Rosvold
Nov 1, 1971·Journal of Comparative and Physiological Psychology·P S GoldmanT W Galkin
Oct 1, 1993·Neuropsychologia·S J AngeliM Mishkin
Dec 1, 1952·Journal of Comparative and Physiological Psychology·K H PRIBRAMS J KAPLAN
Nov 1, 1957·Journal of Neurophysiology·M MISHKIN
Aug 1, 1960·Journal of Comparative and Physiological Psychology·K BATTIGM MISHKIN

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Citations

Mar 27, 2003·Animal Cognition·Sylvain FisetFrance Landry
Aug 31, 2006·Animal Cognition·Camille Ward, Barbara B Smuts
Feb 24, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·B AdamsN W Milgram
Feb 24, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·K L Overall
Feb 24, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·A Kosmal
Feb 24, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·D M Kowalska
Jul 1, 1997·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J H WangP T Kelly
Nov 5, 2004·Developmental Neuropsychology·Ariel Lyons-WarrenTamara Hershey
Sep 18, 2015·Pediatric Diabetes·Katherine SemenkovichAna Maria Arbeláez
Apr 9, 2014·Frontiers in Pharmacology·Paulina R Davis, Elizabeth Head
Nov 3, 2020·Frontiers in Veterinary Science·László LehnerGábor Nagy

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