Effects of hirudin (thrombin specific inhibitor) in zebrafish embryos: a developmental role for thrombin

Blood Cells, Molecules & Diseases
P JagadeeswaranC A Eddy

Abstract

To address the role of thrombin in early embryogenesis, hirudin, a thrombin specific inhibitor was microinjected into developing zebrafish embryos to inhibit the temporal activity of thrombin during early embryonic development. We found that the fibrin forming activity is inhibited by the presence of hirudin. We also found that hirudin affects development in zebrafish embryos suggesting thrombin's role in early embryogenesis. This ability to inhibit thrombin activity in developing embryos should facilitate studies on identifying signal transduction pathways affected by thrombin during embryogenesis.

References

Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·L B Chen, J M Buchanan
May 1, 1990·Journal of Neurochemistry·K P CavanaughR A Bradshaw
Feb 16, 1991·Biochimica Et Biophysica Acta·C S Jamison, S J Degen
Jan 1, 1980·Annual Review of Biochemistry·C M Jackson, Y Nemerson
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Jan 1, 1996·Seminars in Thrombosis and Hemostasis·C A McNamaraG K Owens
Jan 1, 1996·Seminars in Thrombosis and Hemostasis·R B Wallis
Aug 1, 1997·Blood Cells, Molecules & Diseases·P Jagadeeswaran, Y C Liu

❮ Previous
Next ❯

Citations

Aug 1, 2007·Journal of Thrombosis and Haemostasis : JTH·P JagadeeswaranS Kim
Nov 3, 2004·Clinics in Perinatology·Michael J PaidasYale S Arkel
Dec 9, 2000·Blood Cells, Molecules & Diseases·P JagadeeswaranR Hanumanthaiah
Feb 8, 2002·Blood Cells, Molecules & Diseases·R HanumanthaiahP Jagadeeswaran
Feb 13, 2016·PloS One·Evelien SchurgersBas de Laat
Nov 25, 2003·Hematology·Theodore E WarkentinJacob H Rand

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Blood Cells, Molecules & Diseases
P Jagadeeswaran, Y C Liu
Alcoholism, Clinical and Experimental Research
K G Mann
Proceedings of the National Academy of Sciences of the United States of America
M C Fishman
© 2021 Meta ULC. All rights reserved