PMID: 9160852Apr 1, 1997Paper

Effects of histamine agents on methamphetamine-induced stereotyped behavior and behavioral sensitization in rats

Psychopharmacology
C ItoM Sato

Abstract

In this study, effects of histamine (HA) agents on methamphetamine (METH)-induced stereotyped behavior and behavioral sensitization were examined in rats. Pretreatment with a precursor of HA, L-histidine (750mg/kg), significantly inhibited the METH (3 mg/kg)-induced stereotyped behavior, whereas pretreatment with an inhibitor of HA synthesis, alpha-fluoromethylhistidine (FMH) (100 mg/kg), an H1 antagonist pyrilamine (5 mg/kg) or an H2 antagonist zolantidine (5 mg/kg) enhanced it. The inhibitory effect of L-histidine on METH-induced stereotyped behavior was significantly blocked by coadministration of pyrilamine and zolantidine, indicating that the effect is mediated through H1 and H2 receptors. Moreover, chronic treatment with METH (3 mg/kg) significantly enhanced stereotyped behavior at the rechallenge with METH (1 mg/kg). Chronic treatment with L-histidine (750 mg/kg) plus METH inhibited the METH-induced argumentation of stereotyped behavior, while that with FMH (100 mg/kg), pyrilamine (5 mg/kg) or zolantidine (5 mg/kg) potentiated it. These findings suggest that the HA neuron system has an inhibitory role in METH-induced stereotyped behavior and behavioral sensitization.

Citations

Feb 1, 2003·Biochemical and Biophysical Research Communications·Junichi KitanakaMotohiko Takemura
Aug 5, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·C Ito
May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Summer F AcevedoJacob Raber
Nov 10, 2009·Pharmacology, Biochemistry, and Behavior·Junichi KitanakaMotohiko Takemura
Oct 22, 2008·Pharmacology, Biochemistry, and Behavior·Zhixia Wang, William L Woolverton
Nov 16, 2004·Annals of the New York Academy of Sciences·Kentaro IwabuchiKazuhiko Yanai
Feb 8, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Kentaro IwabuchiKazuhiko Yanai
Apr 7, 2011·Brain Research·Summer F Acevedo, Jacob Raber
Jan 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Patrik MunzarSteven R Goldberg
Mar 12, 2016·Drug Target Insights·Junichi KitanakaMotohiko Takemura
Nov 9, 2000·The European Journal of Neuroscience·O V AnichtchikP Panula

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