Effects of histamine on acetylcholine release in bullfrog sympathetic ganglia

European Journal of Pharmacology
M YamadaK Koketsu

Abstract

The effects of histamine on the release of acetylcholine (ACh) from bullfrog sympathetic preganglionic nerve terminals were examined by means of intracellular microelectrode techniques. Low concentrations of histamine (1, 3 muM) increased the amplitude of fast excitatory postsynaptic potentials (fast EPSPs) and ACh quantal content, while high concentrations (100, 300 muM) decreased the amplitude and content. Amplitudes of miniature EPSPs and ACh potentials were not affected by histamine (0.3-300 muM). The facilitatory effect of histamine on fast EPSPs disappeared in the presence of mepyramine, whereas the depressant effect of histamine on fast EPSPs disappeared in the presence of cimetidine. These results suggest that histamine has facilitatory and depressant actions on ACh release. The facilitatory action is probably mediated by the H1-receptor and the depressant action by the H2-receptor, both of which are located at the presynaptic nerve terminals of bullfrog sympathetic ganglia.

References

Aug 1, 1972·Canadian Journal of Physiology and Pharmacology·H E Brezenoff, S B Gertner
Nov 16, 1973·Nature·M J Brimble, D I Wallis
Aug 1, 1965·Journal of Cellular Physiology·S NishiK Koketsu
Nov 1, 1980·British Journal of Pharmacology·K Hirai, K Koketsu
Dec 1, 1954·British Journal of Pharmacology and Chemotherapy·U TRENDELENBURG
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Feb 1, 1960·Journal of Cellular and Comparative Physiology·S NISHI, K KOKETSU

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Citations

Dec 1, 1988·Cellular and Molecular Neurobiology·S A Springfield, H M Geller
Jul 29, 1985·Brain Research·O HäppöläP Panula
May 8, 1985·European Journal of Pharmacology·R Rubinstein, S Cohen
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T TaneikeA Ohga
Oct 1, 1985·Experimental Neurology·D Weinreich
May 1, 1985·British Journal of Pharmacology·M AriyoshiT Tokimasa

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