PMID: 8603259Mar 1, 1996Paper

Effects of HIV-1 Tat on expression of HLA class I molecules

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
M MatsuiJ A Frelinger

Abstract

Tat protein of HIV-1 is a potent transactivator of transcription and essential for HIV-1 replication. In addition, Tat has been proposed to possess immunosuppressive functions, suggesting that Tat may play a direct role in the immune dysfunction associated with AIDS. Recently, it has been reported that Tat represses activity of a major histocompatibility complex (MHC) class I gene promoter. Because HIV infection downmodulates expression of class I molecules, this data strongly suggests that Tat downregulates class I expression and leads to loss of CTL activity. Here, we report effects of Tat on class I expression using a human cell line, T0, expressing Tat (TO-Tat). Northern blot analysis shows that levels of MHC class I transcripts are normal in T0-Tat. Flow cytometry analyses indicate that expression of HLA class I molecules is not substantially downregulated to any great extent by Tat in T0-Tat. Further, pulse-chase experiments followed by Endoglycosidase-H treatment show that the rate of maturation and processing of class I molecules in T0-Tat is indistinguishable from that in the original cell line, T0. Taken together, these data suggest that Tat expression does not necessarily result in downregulation of class I expression.

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Citations

Jul 1, 1997·Journal of Biomedical Science·T. LuoJ.V. Garcia
Aug 1, 1996·Current Opinion in Immunology·B AutranG Haas
Sep 6, 2000·Current Opinion in Microbiology·C Brander, B D Walker
Feb 15, 2001·Journal of Hematotherapy & Stem Cell Research·S Agrawal, M C Kishore
Mar 15, 2013·Journal of Virology·Raabya RossenkhanM Essex
Jan 6, 2011·Expert Opinion on Biological Therapy·Manish K JohriSunit K Singh
Oct 9, 2009·The Journal of General Virology·Bizhan RomaniRichard H Glashoff
Feb 27, 2004·European Journal of Clinical Investigation·M C D G HuigenH S L M Nottet
Aug 30, 2000·European Journal of Clinical Investigation·W KampH S Nottet
Jan 8, 2005·Journal of Leukocyte Biology·David J VigerustVirginia L Shepherd
Feb 4, 2003·Nature Reviews. Immunology·B Matija Peterlin, Didier Trono
Aug 30, 2013·The Open Virology Journal·Wasim Abbas, Georges Herbein
Mar 10, 2001·Scandinavian Journal of Infectious Diseases·S A Calarota, B Wahren

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