Abstract
To examine the association between the duration of HIV infection and the stage of cervical cancer in Lusaka, Zambia. This retrospective case-case study included 1583 cervical cancer patients from the Cancer Diseases Hospital in Lusaka, Zambia. A sub-population of HIV-positive patients with additional clinical HIV information was identified following linkage of cancer and HIV databases. Logistic regression models examined the relationship between HIV status and early-onset cervical cancer diagnosis, and between HIV infection duration and initial diagnosis of metastatic cervical cancer. The study population had an average age of 49 years and 40.9% had an initial diagnosis of metastatic cancer. HIV-positive women were more than twice as likely to be diagnosed at early-onset cervical cancer compared with HIV-negative women. Among the sub-population of HIV-positive patients, a longer duration of HIV infection was associated with 20% lowered odds of initial metastatic cancer diagnosis. The availability, accessibility, and impact of the cervical screening program in this population should be further examined to elucidate the relationship between cervical screening, age, and duration of HIV infection and the the stage of diagnosis of c...Continue Reading
References
Feb 6, 1988·British Medical Journal·C A MeanwellG Blackledge
Nov 14, 1997·The New England Journal of Medicine·X W SunT C Wright
Jul 20, 2007·BMC Infectious Diseases·Christopher Ng'andwePeter C Angeletti
Oct 23, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Hugo De VuystJennifer S Smith
Jun 6, 2009·Health Policy and Planning·Regien G BiesmaGill Walt
May 26, 2011·PLoS Medicine·Mulindi H MwanahamuntuGroesbeck P Parham
Jul 11, 2012·Health Affairs·Karen A Grépin
Jul 11, 2012·Health Affairs·Margaret E KrukWafaa El-Sadr
Oct 24, 2012·Obstetrics and Gynecology·Vicki B BenardMona Saraiya
Jul 2, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gita SunejaEric A Engels
Nov 26, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mulele KalimaAmr S Soliman
Mar 6, 2015·Cancer·Meredith S ShielsEric A Engels
Apr 18, 2015·PloS One·Groesbeck P ParhamVikrant V Sahasrabuddhe
Jun 17, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anna E CoghillEric A Engels
Jul 25, 2015·BMC Cancer·Allen C BatemanCarla J Chibwesha
Mar 29, 2016·Health Policy and Planning·Samuel Abimerech LubogaAmy Hagopian
Aug 15, 2017·The Lancet. HIV·Raúl U Hernández-RamírezEric A Engels
Aug 19, 2017·Gynecologic Oncology Reports·Rahel G GhebreHannah Simonds
Sep 7, 2017·Sexually Transmitted Diseases·Qiang XiaLucia V Torian
Sep 13, 2018·CA: a Cancer Journal for Clinicians·Freddie BrayAhmedin Jemal
Mar 23, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mario Jesus TrejoAmr Soliman