Effects of HMG-CoA reductase inhibition on erythrocyte membrane cholesterol and acyl chain composition

Clinica Chimica Acta; International Journal of Clinical Chemistry
J F DwightB M Hendry

Abstract

The effects of 2 months treatment with simvastatin (40 mg, 20 mg p.o. daily) or placebo on erythrocyte membrane cholesterol content and acyl chain composition have been studied in 36 patients with a clinical history of atherosclerosis enrolled in the Oxford Cholesterol Study. All patients received advice corresponding to a standard phase 1 cholesterol-lowering diet. As expected the mean serum total cholesterol fell substantially (-26.5%, 20 mg simvastatin, P < 0.05; -32.7%, 40 mg simvastatin, P < 0.05) compared to placebo (-6.3%, ns). However, mean erythrocyte cholesterol content did not change significantly in any group (2 months therapy: 20 mg simvastatin, -0.62%; 40 mg simvastatin, +2.2%; placebo, -4.2%). Erythrocyte cholesterol was also unaltered after 5 months of therapy. Erythrocyte osmotic fragility was unchanged in the treatment and placebo groups. In the placebo group dietary advice alone was associated with a significant increase in the linoleic acid content of erythrocytes from 9.4 mole% of total acyl chains to 11.8 mole% (P < 0.05). Treatment with simvastatin was associated with an increase in the arachidonic acid content of the erythrocyte membrane from 12.2 to 15.3 mole% (P < 0.05). Treatment with simvastatin does...Continue Reading

References

Nov 1, 1992·Journal of the Neurological Sciences·K NakaharaM Osame
Feb 15, 1992·BMJ : British Medical Journal·G Davey Smith, J Pekkanen
Feb 15, 1992·BMJ : British Medical Journal·M F Oliver
May 1, 1991·Experimental Physiology·F J LucioJ C Ellory
Jan 1, 1989·Advances in Enzyme Regulation·A Endo, K Hasumi
Aug 25, 1989·Pharmaceutisch Weekblad. Scientific Edition·J J van DoormaalH Doorenbos
Dec 30, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·E PeuchantR Jensen
Jul 7, 1988·The New England Journal of Medicine·S M Grundy
Apr 1, 1968·The Journal of Clinical Investigation·C F Reed
May 13, 1982·Biochimica Et Biophysica Acta·R B Shireman, J F Remsen
Jun 23, 1981·Biochimica Et Biophysica Acta·D Y HuiJ A Harmony
Mar 1, 1983·Biochimica Et Biophysica Acta·J P Slotte, B Lundberg
May 1, 1963·The Journal of Clinical Investigation·J W FARQUHAR, E H AHRENS

❮ Previous
Next ❯

Citations

Oct 20, 2009·Cardiovascular Drugs and Therapy·Dimitrios N TziakasStavros Konstantinides
Oct 29, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M J BelliniM G de Bravo
Feb 11, 2010·The Journal of Membrane Biology·Mariana Vaini de FreitasNilson Penha-Silva
Dec 4, 2003·The International Journal of Biochemistry & Cell Biology·Maria KoterJulita Chojnowska-Jezierska
May 27, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·John O NyalalaW Grady Smith
Aug 18, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Jennifer I HarrisMatthew F Muldoon
May 6, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Claudio Galli
May 6, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Michel de LorgerilJoël de Leiris
Jul 16, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Antti JulaRisto Huupponen
May 31, 2003·Canadian Journal of Physiology and Pharmacology·Maria KoterJulita Chojnowska-Jezierska
Jan 22, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Bruno StiegerKaspar P Locher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.