PMID: 8942834Dec 1, 1996Paper

Effects of hormonal replacement therapy on the postural balance among postmenopausal women

Obstetrics and Gynecology
M HammarM K Niklasson

Abstract

To establish whether hormone replacement therapy affects postural balance in postmenopausal women. Nineteen healthy postmenopausal women with vasomotor symptoms were included. Median age was 54 years, median time since menopause was 3 years. They underwent dynamic posturography before and after 4 and 12 weeks of transdermal estrogen treatment (17 beta-estradiol 50 micrograms/day) as well as after 2 additional weeks of combined estrogen-progestagen treatment. The dynamic posturography method quantifies the amplitude, frequency, and pattern of body sway and tests the visual, vestibular, and somatosensory systems, which together maintain balance. The two most difficult tests either cancel visual and distort somatosensory inputs or give distorted information from both the visual and somatosensory systems. Hormone replacement therapy increased static balance performance assessed by dynamic posturography. A highly significant improvement was seen in the two most difficult tests between the pretreatment test and the test performed after 4 weeks of estrogen therapy (P < .01, P < .001, respectively). This improvement was sustained after 12 weeks and also during the 14th week, with the women on combined estrogen-progestagen treatment. Es...Continue Reading

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Dec 20, 2005·Psychopharmacology·Anna-Carin N-WihlbäckTorbjörn Bäckström
Jul 5, 2001·Neuroscience Letters·C L DarlingtonP F Smith
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