PMID: 11329233May 1, 2001Paper

Effects of hormone replacement therapy on serum lipids in elderly women. a randomized, placebo-controlled trial

Annals of Internal Medicine
E F BinderW M Kohrt

Abstract

Coronary heart disease (CHD) is the leading cause of death among older women. In observational studies, the incidence of CHD has been reduced in postmenopausal women who take hormone replacement therapy (HRT). A low serum level of high-density lipoprotein (HDL) cholesterol is one of the risk factors predictive of death from CHD. To determine the effects of HRT on serum lipid and lipoprotein levels in elderly women. Randomized, double-blind, placebo-controlled trial. University research center. 59 sedentary women 75 years of age or older. Participants were assigned to 9 months of oral therapy with placebo or conjugated estrogens, 0.625 mg/d, plus trimonthly medroxyprogesterone acetate, 5 mg/d for 13 days. Serum lipid and lipoprotein levels. After 9 months of treatment, women in the HRT group compared with women in the placebo group had decreased low-density lipoprotein cholesterol levels (mean change [+/-SD], -0.47 +/- 0.69 mmol/L [-18.2 +/- 26.5 mg/dL] vs. -0.06 +/- 0.32 mmol/L [-2.2 +/- 12.2 mg/dL], respectively; between-group difference, 0.41 mmol/L [95% CI, 0.09 to 0.74 mmol/L], 16 mg/dL [95% CI, 3.5 to 28.5 mg/dL]; P = 0.01) and increased HDL cholesterol levels (mean change, 0.21 +/- 0.27 mmol/L [8.1 +/- 10.5 mg/dL] vs. 0.0...Continue Reading

Citations

Jul 2, 2002·The American Journal of Geriatric Cardiology·Marian C Limacher
Feb 24, 2006·Journal of Cardiovascular Pharmacology·Jeffrey T KuvinRichard H Karas
Dec 17, 2009·Health Informatics Journal·Sharon J RolnickJerry H Amundson
Sep 18, 2001·Journal of Women's Health & Gender-based Medicine
Jun 24, 2015·Current Opinion in Lipidology·Tarza J SiahmansurHandrean Soran
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·R E Van PeltW M Kohrt
Mar 16, 2002·Cardiology in Review·Charles E Rackley
Jan 22, 2002·Current Opinion in Lipidology·J Shepherd
Jan 11, 2007·Breast Cancer Research and Treatment·Sonal Gandhi, Sunil Verma
Dec 17, 2015·Archives of Gynecology and Obstetrics·Stefano BoglioloArsenio Spinillo
Jun 24, 2004·Journal of General Internal Medicine·Shelley R SalpeterEdwin E Salpeter
Mar 16, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Tomohiro OkuraKiyoji Tanaka
Jul 16, 2009·The Journal of Clinical Endocrinology and Metabolism·Thomas MünzerMarc R Blackman
Nov 1, 2011·Hormone Molecular Biology and Clinical Investigation·Joaquín Cortés-PrietoHugh Ahern
Dec 17, 2009·Clinical Science·Hilary V O CarswellTracy D Farr

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