Effects of hot water extract of Curcuma longa on human epidermal keratinocytes in vitro and skin conditions in healthy participants: A randomized, double-blind, placebo-controlled trial

Journal of Cosmetic Dermatology
Kazuki AsadaShinji Murosaki

Abstract

Curcuma longa has been reported to have anti-inflammatory effects. Skin inflammation impairs skin functions. Our aim was to investigate the effect of a hot water extract of C longa (WEC) on skin conditions in cell studies using keratinocytes and in clinical trials. We measured proinflammatory cytokine levels in ultraviolet B-irradiated keratinocytes in the presence or absence of WEC. The effects of WEC on hyaluronan production in keratinocytes were also determined. In a randomized, double-blind, placebo-controlled trial, 47 healthy participants were assigned to 8-week intervention groups with daily intakes of WEC with or without curcumin or a placebo. The water content and transepidermal water loss in the face and minimal erythema dose on the back after ultraviolet B irradiation were evaluated every 4 weeks. Hot water extract of C longa significantly inhibited increases in ultraviolet B-induced tumor necrosis factor α and interleukin 1β at the mRNA and protein levels. WEC also significantly increased hyaluronan production from nonstimulated keratinocytes. In the randomized, double-blind, placebo-controlled trial, increases from baseline in the water content of the face were significantly greater at weeks 4 and 8 in the WEC grou...Continue Reading

References

Oct 1, 1992·Experimental Dermatology·F FantiniA Giannetti
May 24, 1996·Biochemical and Biophysical Research Communications·N Itano, K Kimata
Sep 20, 1996·The Journal of Biological Chemistry·A P SpicerJ A McDonald
Apr 4, 1997·The Journal of Biological Chemistry·A P SpicerJ A McDonald
Feb 3, 1998·Journal of the American Academy of Dermatology·B Eberlein-KönigB Przybilla
Feb 24, 1998·Clinics in Dermatology·D Rudikoff
Mar 14, 1998·Acta Dermato-venereologica·A Di NardoS Seidenari
Feb 20, 2002·The Journal of Investigative Dermatology·Tetsuya SayoShintaro Inoue
Nov 5, 2002·Journal of Ethnopharmacology·Z F YuY Chen
Jan 7, 2003·IUBMB Life·Naoki Itano, Koji Kimata
Dec 6, 2005·Biological & Pharmaceutical Bulletin·Kazue TsukaharaYoshinori Takema
Jan 24, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gertrude-E Costin, Vincent J Hearing
Dec 27, 2007·Archives of Biochemistry and Biophysics·Ikuko KakizakiKeiichi Takagaki
Jul 9, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lesley E RhodesAnna Nicolaou
Aug 8, 2009·The American Journal of Pathology·Nina KirschnerJohanna M Brandner
Oct 7, 2010·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Z-X Jiang, J DeLaCruz
Aug 14, 2012·Molecular Nutrition & Food Research·Subash C GuptaBharat B Aggarwal
Jul 3, 2013·North American Journal of Medical Sciences·Parveen Dahiya, Reet Kamal
Jun 14, 2014·Journal of Photochemistry and Photobiology. B, Biology·Ana L M IvanRúbia Casagrande
Nov 18, 2017·Journal of Bioscience and Bioengineering·Keiko MutaSatoshi Amano

❮ Previous
Next ❯

Citations

Jan 23, 2020·Journal of Materials Science. Materials in Medicine·Virginia CampaniGiuseppe De Rosa
Sep 13, 2019·Nutrients·Laura VollonoElena Campione
Feb 2, 2021·Clinical and Experimental Dermatology·S M BarbalhoB de Alvarez Rezende

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.