PMID: 9539069Apr 16, 1998Paper

Effects of human recombinant growth hormone (rhGH) on inflammatory responses in patients undergoing abdominal aortic aneurysm repair

Intensive Care Medicine
K MealyD Bouchier-Hayes

Abstract

Human recombinant growth hormone (rhGH) has been shown to increase skeletal muscle protein synthesis and improve nitrogen balance in critically ill patients and those undergoing surgery. rhGH effects on hepatic protein turnover in critically ill patients are less clearly understood. To examine rhGH effects on hepatic acute phase protein responses and inflammatory cytokine release in patients undergoing major surgery. Prospective double blind randomised trial. Tertiary referral university teaching hospital. Patients undergoing elective abdominal aortic aneurysm repair. Patients received rhGH (Genotropin, 0.3 IU/kg per day, n = 8) or placebo (n = 10) for 6 days prior to surgery. Blood levels of growth hormone (GH) and insulin-like growth factor (IGF-1) were measured following rhGH treatment and C-reactive protein (CRP), serum amyloid A (SAA) and the cytokines interleukin-6 (IL-6) and the IL-1 receptor antagonist (IL-1ra) were measured for up to 24 h following surgery. Significant increases in plasma rhGH (0.84 +/- 0.3, mean (sem) versus 52 +/- 20 mU/l, p < 0.0008) and IGF-1 levels (119 +/- 13 versus 644 +/- 110 ng/ml, p < 0.0001) were seen prior to surgery following rhGH administration. No differences in acute phase protein or cy...Continue Reading

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Citations

Jan 10, 2006·Critical Care Clinics·Teng Teng Chung, Charles J Hinds
Jan 12, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P V Carroll
Jan 22, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·P V Carroll
Sep 14, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·T TashiroN Nakajima
Jun 6, 2009·The Journal of Clinical Endocrinology and Metabolism·Liping ChungRobert C Baxter
Mar 9, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Rory J BonnerSuzanne H Richards

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