Abstract
Human recombinant growth hormone (rhGH) has been shown to increase skeletal muscle protein synthesis and improve nitrogen balance in critically ill patients and those undergoing surgery. rhGH effects on hepatic protein turnover in critically ill patients are less clearly understood. To examine rhGH effects on hepatic acute phase protein responses and inflammatory cytokine release in patients undergoing major surgery. Prospective double blind randomised trial. Tertiary referral university teaching hospital. Patients undergoing elective abdominal aortic aneurysm repair. Patients received rhGH (Genotropin, 0.3 IU/kg per day, n = 8) or placebo (n = 10) for 6 days prior to surgery. Blood levels of growth hormone (GH) and insulin-like growth factor (IGF-1) were measured following rhGH treatment and C-reactive protein (CRP), serum amyloid A (SAA) and the cytokines interleukin-6 (IL-6) and the IL-1 receptor antagonist (IL-1ra) were measured for up to 24 h following surgery. Significant increases in plasma rhGH (0.84 +/- 0.3, mean (sem) versus 52 +/- 20 mU/l, p < 0.0008) and IGF-1 levels (119 +/- 13 versus 644 +/- 110 ng/ml, p < 0.0001) were seen prior to surgery following rhGH administration. No differences in acute phase protein or cy...Continue Reading
References
Nov 1, 1992·Endocrinology·R KooijmanB J Zegers
Feb 1, 1991·Endocrinology·C K EdwardsK W Kelley
Oct 1, 1990·Annals of Surgery·D N HerndonR L Rutan
Oct 1, 1989·Annals of Surgery·Z M JiangD W Wilmore
Feb 12, 1988·Science·C K EdwardsK W Kelley
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K W KelleyE B Walker
Feb 27, 1988·Lancet·G A PontingA J Sim
Apr 1, 1985·The Journal of Clinical Endocrinology and Metabolism·W Kiess, O Butenandt
Apr 1, 1987·World Journal of Surgery·F B Cerra
Jan 1, 1987·Journal of Neuroscience Research·D R DavilaK W Kelley
Nov 1, 1967·Annals of Surgery·H S SoroffM S Raben
Jan 1, 1982·Annals of the New York Academy of Sciences·I Kushner
Nov 1, 1995·Annals of Surgery·C GoetersD Löhlein
Jul 1, 1995·Clinical Immunology and Immunopathology·E M O'NualláinD J Reen
Aug 1, 1995·The British Journal of Surgery·M MjaalandA Revhaug
Mar 1, 1994·Endocrinology·T H ElsasserG F Hartnell
Jul 1, 1993·World Journal of Surgery·R Vara-ThorbeckJ M Capitán
Oct 1, 1995·European Journal of Clinical Investigation·R SandströmK Lundholm
Feb 1, 1996·The British Journal of Surgery·J B KoeaJ H Shaw
Oct 30, 1996·Journal of Immunological Methods·C C McCormackA S Whitehead
Citations
Jan 10, 2006·Critical Care Clinics·Teng Teng Chung, Charles J Hinds
Jan 12, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P V Carroll
Jan 22, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·P V Carroll
Apr 26, 2001·The Journal of Surgical Research·D MoneleyD J Bouchier Hayes
Sep 14, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·T TashiroN Nakajima
Jun 6, 2009·The Journal of Clinical Endocrinology and Metabolism·Liping ChungRobert C Baxter
Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·S H Zarkesh-EsfahaniR J Ross
Jul 2, 2005·World Journal of Gastroenterology : WJG·Yong ZhouMao-Ling Wei
Mar 9, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Rory J BonnerSuzanne H Richards