Effects of human umbilical cord mesenchymal stem cells on co-cultured ovarian carcinoma cells

Microscopy Research and Technique
Xiufeng Li, Zongming Li

Abstract

Ovarian carcinoma is mainly treated by surgery aided by chemotherapy. If supplemented by stem cells treatment, its recurrence rate and mortality rate will be decreased. This is a new therapy. In this study, ovarian cancer cells were cultured together with umbilical cord mesenchymal stem cells (UCMSCs), and the interactions between them were observed. The results showed that the survival rates of UCMSCs increased to 83.8 ± 2.2% from 56.5 ± 5.5%, and the survival rates of ovarian cancer cells decreased to 16.2 ± 2.2% from 43.5 ± 5.5% with the progression of the cultural time from 24 to 96 hr. There was a significant difference between them (p < .05). It revealed that UCMSCs could inhibit the proliferation of ovarian cancer cells.

References

Mar 18, 2015·Experimental and Therapeutic Medicine·Xiaoyi LiuZhigang Yu
Feb 1, 2018·Journal of Immunological Methods·Girja S ShuklaDavid N Krag
Oct 3, 2018·Journal of Visualized Experiments : JoVE·Alaa T AlshareedaMohammed Alahmed

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Citations

Jun 30, 2019·Journal of Cellular Physiology·Hossein AbbaszadehMehdi Yousefi
Jul 23, 2020·Stem Cells International·Yang JiaoBingrong Zheng

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