PMID: 9652Jun 23, 1976

Effects of humoral modulators and naloxone on morphine-induced changes in the spontaneous locomotor activity of the rat

Psychopharmacology
T Oka, E Hosoya

Abstract

The s.c. administration of 20 mg/kg of morphine-HCl produced a decrease in the spontaneous locomotor activity (SLMA) of rats. The decrease in SLMA was significantly antagonized by p-chlorophenylalanine (p-CPA). When rats pretreated with p-CPA were given 5-hydroxytryptophan before morphine injection, the marked sedative response to morphine was restored, suggesting that the morphine-induced decrease in SLMA of rats may depend on the release of 5-hydroxytryptamine by morphine. By contrast, the s.c. administration of 5 mg/kg of morphine-HCl produced a significant increase in SLMA of rats. The magnitude of the increase was reduced by atropine, scopolamine or alpha-methyl-p-tyrosine. It appears that both adrenergic and cholinergic mechanisms participate in the increase in SLMA of rats induced by morphine. Both the increase in SLMA produced by 5 mg/kg of morphine and the decrease in SLMA induced by 20 mg/kg of morphine were completely antagonized by the s.c. administration of naloxone-HCl, 0.0625 and 0.25 mg/kg, respectively. Thus, it appears that the receptor with which morphine interacts to produce stimulation is chemically identical with or very similar to the receptor with which morphine combines to induce depression. The former ...Continue Reading

References

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Citations

Jan 1, 1981·Psychopharmacology·M Leshem
Apr 7, 1977·European Journal of Pharmacology·T Oka, K Negishi
Feb 1, 1989·Physiology & Behavior·L A PohoreckyP Roberts
Jun 1, 1977·Pharmacology, Biochemistry, and Behavior·D Van der Kooy, A G Phillips
Apr 1, 1978·Pharmacology, Biochemistry, and Behavior·R J KatzG Baldrighi
Mar 1, 1981·Pharmacology, Biochemistry, and Behavior·L S Brady, S G Holtzman
Sep 1, 1982·Pharmacology, Biochemistry, and Behavior·W M DavisH B Pace
Jun 1, 1984·Pharmacology, Biochemistry, and Behavior·P Vezina, J Stewart
Mar 1, 1985·Pharmacology, Biochemistry, and Behavior·M T LowyG K Yim
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·C P Dokla
Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·H L KimmelS G Holtzman
Jan 1, 1978·General Pharmacology·T Oka
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Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Anthony S RauhutMichael T Bardo
Sep 6, 2013·Journal of the American Veterinary Medical Association·Tracie R BakerKurt K Sladky
Jan 1, 1981·Psychopharmacology·H de Wit, J Stewart
Apr 28, 2010·Pharmacology, Biochemistry, and Behavior·Xinwang LiCharles P France
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Related Concepts

Metazoa
Atropine Sulfate Anhydrous
5-Hydroxytryptophan
Levopa
Methyltyrosines
Morphine Sulfate (2: 1), Pentahydrate
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Fenclonine Hydrobromide
Isopto Hyoscine
Neurosteroids

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