Effects of hydrogen peroxide on biological characteristics and osteoinductivity of decellularized and demineralized bone matrices

Journal of Biomedical Materials Research. Part a
Quan QingTing-Wu Qin

Abstract

Due to the similar collagen composition and closely physiological relationship with soft connective tissues, demineralized bone matrices (DBMs) were used to repair the injured tendon or ligament. However, the osteoinductivity of DBMs would be a huge barrier of these applications. Hydrogen peroxide (H2 O2 ) has been proved to reduce the osteoinductivity of DBMs. Nevertheless, the biological properties of H2 O2 -treated DBMs have not been evaluated completely, while the potential mechanism of H2 O2 compromising osteoinductivity is also unclear. Hence, the purpose of this study was to characterize the biological properties of H2 O2 -treated DBMs and search for the proof that H2 O2 could compromise osteoinductivity of DBMs. Decellularized and demineralized bone matrices (DCDBMs) were washed by 3% H2 O2 for 12 h to fabricate the H2 O2 -treated DCDBMs (HPTBMs). Similar biological properties including collagen, biomechanics, and biocompatibility were observed between DCDBMs and HPTBMs. The immunohistochemistry staining of bone morphogenetic protein 2 (BMP-2) was negative in HPTBMs. Furthermore, HPTBMs exhibited significantly reduced osteoinductivity both in vitro and in vivo. Taken together, these findings suggest that the BMP-2 in DC...Continue Reading

References

May 10, 2008·Acta Biochimica Et Biophysica Sinica·Yanfang GuoHongwen Deng
Jul 26, 2008·Tissue Engineering. Part a·Janet E ReingStephen F Badylak
Aug 7, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Siva SundarGordon W Blunn
Nov 27, 2009·Nature·Matthias P LutolfHelen M Blau
Jun 17, 2011·Journal of Cellular Biochemistry·Elizabeth SalisburyAlan R Davis
Dec 17, 2011·Biotechnology and Applied Biochemistry·Sangwon Chung, Martin W King
Sep 15, 2012·International Journal of Experimental Pathology·Etienne J O O'BrienDavid A Hart
Sep 18, 2012·The American Journal of Sports Medicine·Vedran LovricWilliam R Walsh
Dec 15, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yun Feng RuiKai Ming Chan
May 8, 2013·Journal of Biomedical Materials Research. Part a·Yushu ChenYanjun Zeng
May 16, 2013·Annals of Surgery·Jonathan R PetersonBenjamin Levi
Nov 14, 2013·The Journal of Craniofacial Surgery·Shima TavakolSeyed Mahdi Rezayat Sorkhabadi
Jun 19, 2014·Chemical Communications : Chem Comm·Roberta BortolozziGiampietro Viola
Oct 3, 2014·Journal of Periodontology·Shan-Huey YuPo-Chun Chang
Oct 23, 2014·International Orthopaedics·Maurice Hinsenkamp, Jean-Francois Collard
Jul 3, 2015·The Journal of Bone and Joint Surgery. American Volume·Kavitha RanganathanBenjamin Levi
Jul 15, 2015·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Giovanni MerollaGiuseppe Porcellini
Jul 17, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chunfeng ZhaoPeter C Amadio
Dec 27, 2015·Seminars in Cell & Developmental Biology·Frederick S KaplanEileen M Shore
Jan 31, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Kairui ZhangMotomi Enomoto-Iwamoto
Feb 26, 2016·ACS Applied Materials & Interfaces·Enrique Martínez-CamposJuan Rodríguez-Hernández
Mar 5, 2016·International Journal of Molecular Medicine·Jia LiJiansheng Su
Jan 1, 2004·Medical Journal, Armed Forces India·V P PathaniaG R Joshi
Dec 13, 2016·Acta Biomaterialia·Laxminarayanan KrishnanRobert E Guldberg
Mar 21, 2017·Human Pathology·Margaret CocksAaron W James
Oct 7, 2017·Journal of Biomedical Materials Research. Part a·Jie-Liang YangTing-Wu Qin
Jun 14, 2018·International Journal of Oral Science·Maria B AsparuhovaVivianne Chappuis

❮ Previous
Next ❯

Citations

Feb 16, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chenyuan GaoChunwu Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomechanics

Biomechanics examines the generation of internal forces within the body and investigates the effects and control of forces that act on or are produced on tissues. Here are the latest discoveries.

Related Papers

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Yue Fang, Zhiming Yang
Anales de la Real Academia Nacional de Medicina
J Borrachero del Campo
© 2022 Meta ULC. All rights reserved