PMID: 11318359Apr 25, 2001Paper

Effects of hydromorphone or oxymorphone, with or without acepromazine, on preanesthetic sedation, physiologic values, and histamine release in dogs

Journal of the American Veterinary Medical Association
L J SmithK Waller

Abstract

To compare hydromorphone with oxymorphone, with or without acepromazine, for preanesthetic sedation in dogs and assess changes in plasma concentration of histamine after drug administration. Randomized clinical study. 10 healthy mixed-breed dogs. Dogs were treated IM with hydromorphone (group H), oxymorphone (group O), hydromorphone with acepromazine (group H/A), or oxymorphone with acepromazine (group O/A). Sedation score, heart rate, respiratory rate, systolic blood pressure, and oxygen saturation were recorded at baseline immediately after drug administration (T0) and every 5 minutes for 25 minutes (T25). Plasma histamine concentration was measured at baseline and T25. Sedation was similar between groups H and 0 at all times. Sedation was significantly greater for groups H/A and O/A from T10 to T25, compared with other groups. Systolic blood pressure was significantly reduced at T25 in group H/A, compared with group H, and in group O/A, compared with group O. Prevalence of panting at T25 was 50% for groups H and O, compared with 20% for group H/A and 30% for group O/A. By T25, heart rate was significantly lower in all groups. Oxygen saturation was unaffected by treatment. Mean +/- SD plasma histamine concentration was 1.72 +...Continue Reading

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Citations

Aug 5, 2008·Journal of Feline Medicine and Surgery·Sheilah A RobertsonBenedict Duncan X Lascelles
Oct 18, 2006·Journal of the American Veterinary Medical Association·Kristen G Hunyady, Rebecca A Johnson
Mar 22, 2014·Journal of the American Veterinary Medical Association·Ronald B KohSheilah A Robertson
Apr 5, 2014·Journal of the American Veterinary Medical Association·Carolina H Riccó, Natalia Henao-Guerrero
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May 3, 2014·Journal of the American Veterinary Medical Association·Bonnie L Hay Kraus
Oct 15, 2014·Journal of the American Veterinary Medical Association·Bonnie L Hay Kraus
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Feb 20, 2008·Veterinary Anaesthesia and Analgesia·Butch KuKanichLesley J Smith
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