PMID: 9558688Apr 29, 1998Paper

Effects of hydrophilic and lipophilic beta-blockers on heart rate variability and baroreflex sensitivity in normal subjects

Pacing and Clinical Electrophysiology : PACE
M V PitzalisP Rizzon

Abstract

To evaluate the effect of a hydrophilic and a lipophilic beta-blocker on the autonomic nervous system, 20 normal subjects were studied under baseline conditions and 7 days after being randomly assigned to metoprolol (200 mg/day), nadolol (80 mg/day), and placebo. Under each condition, the time-domain parameters were analyzed by means of 24-hour ECG monitoring and the frequency-domain parameters by means of the autoregressive method using 10-minute ECGs during rest, controlled respiration, and after a head-up tilt test. The alpha index (the gain in the relationship between the RR period and systolic arterial pressure variability) was also calculated. Both nadolol and metoprolol significantly increased all of the time-domain parameters except the standard deviation of the RH intervals; they also modified the frequency-domain parameters. Both blunted the significant reduction in the high frequency (HF) component and alpha index during tilt. In normal subjects, hydrophilic and lipophilic beta-blockers similarly modify the time- and frequency-domain parameters that are particularly evident when high sympathetic tone is present (during daytime and tilt). The value of the alpha index was increased by both beta-blockers in the HF, but ...Continue Reading

References

Mar 1, 1978·Cardiovascular Research·A TakeshitaM Nakamura
Sep 1, 1976·Journal of Applied Physiology·D L EckbergA L Mark
Jul 1, 1991·Journal of the Autonomic Nervous System·M PaganiA Malliani
Feb 11, 1991·Journal of the American College of Cardiology·J R CookL M Rolnitzky
Feb 1, 1972·Circulation Research·T G PickeringP Sleight
Feb 1, 1995·European Heart Journal·M V PitzalisP Rizzon
May 1, 1994·Journal of the American College of Cardiology·M J NiemeläH V Huikuri
Nov 1, 1993·Journal of Applied Physiology·T E BrownD L Eckberg

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Citations

Nov 1, 2001·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·J S PerkiömäkiA J Moss
Jan 15, 2005·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Grzegorz GielerakMarian Cholewa

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