PMID: 8964745Mar 1, 1996Paper

Effects of hydrostatic pressure on matrix synthesis in different regions of the intervertebral disk

Journal of Applied Physiology
H IshiharaA C Hall

Abstract

The intervertebral disk is routinely subjected to compressive loads that alter with posture and muscle activity and can produce pressures > 2 MPa in human lumbar disks in vivo (A. Nachemson and G. Elfstrom. Scand. J. Rehabil. Med. 2, Suppl. 1:1-40, 1979; A. Nachemson and J. M. Morris. J. Bone Jt. Surg. Am. Vol. 46A: 1077-1092, 1964). We measured the effect of load on hydrostatic pressures in bovine caudal disks. With increase in applied load, pressure increased linearly in the nucleus and inner annulus. The resting pressure measured after slaughter (0.19 +/- 0.05 MPa) and the pressure at failure (34 MPa, estimated from the vertebrae/disk segment failure load of 7,430 +/- 590 N) define the limits that can occur in vivo. Because hydrostatic pressure influences matrix synthesis in articular cartilage, we have examined the effects of pressures in the range 1-10 MPa applied for 20 s or 2 h on proteoglycan synthesis in bovine caudal and human lumbar intervertebral disks in vitro. In the nucleus pulposus and inner annulus of bovine disks, application of hydrostatic pressure in the range of 1-7.5 MPa for only 20 s stimulated matrix synthesis over the following 2 h at atmospheric pressure. The maximum stimulation in the bovine disks was...Continue Reading

Citations

Jan 13, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H Ishihara, J P Urban
Nov 27, 2004·Spine·Lori A Setton, Jun Chen
Oct 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jeffery J MacleanJames C Iatridis
Jul 1, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Stephan ZeiterKeita Ito
Jul 17, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Casey L KoreckiJames C Iatridis
Sep 17, 2008·Spine·Glenn R Buttermann, Brian P Beaubien
Jun 16, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Cornelia Neidlinger-WilkeJill Urban
Oct 15, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Sandra ReitmaierHans-Joachim Wilke
Jul 8, 2015·International Journal of Molecular Sciences·Derek H RosenzweigLisbet Haglund
Mar 22, 2018·Nature Reviews. Rheumatology·Laurence Vico, Alan Hargens
Dec 21, 2018·JOR Spine·Bailey V FearingNadeen O Chahine
Aug 31, 2001·Journal of Cellular Biochemistry·M K ElfervigA J Banes
Jun 12, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mehran KasraJoseph Buckwalter
May 26, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Yvonne SchroederFrank P T Baaijens
Nov 10, 2004·Journal of Cellular Biochemistry·Mika A EloMikko J Lammi
May 9, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Cornelia Neidlinger-WilkeLutz E Claes
Feb 6, 2008·The Journal of Biological Chemistry·Sarit-Sara SivanAlice Maroudas
Apr 30, 2008·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·A MeirJ P Urban
Mar 22, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·S RajasekaranAjoy P Shetty
Jan 22, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Bin NingShang-You Yang
May 5, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Samantha C W ChanBenjamin Gantenbein-Ritter
Oct 26, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stefan DudliStephen J Ferguson
Mar 18, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Nicola C FosterAlicia J El Haj

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biomechanics and Modeling in Mechanobiology
Shih-Youeng ChuangThomas P Hedman
AJNR. American Journal of Neuroradiology
C Nguyen-minhV M Haughton
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
H OhshimaD H Bergel
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
H S Ranu
© 2021 Meta ULC. All rights reserved