Effects of hydroxyapatite reinforcement on the architecture and mechanical properties of freeze-dried collagen scaffolds

Journal of the Mechanical Behavior of Biomedical Materials
Robert J Kane, Ryan K Roeder

Abstract

Freeze-dried collagen scaffolds reinforced with hydroxyapatite (HA) are of clinical interest for synthetic bone graft substitutes and tissue engineering scaffolds, but a systematic evaluation of the effects of the HA reinforcement weight fraction and morphology on the mechanical properties is lacking. Therefore, freeze-dried collagen scaffolds were reinforced with either HA whiskers or an equiaxed HA powder at 1:1, 1:2, or 1:4 collagen:HA by weight (which corresponded to approximately 28, 44, and 61 vol% HA, respectively) to investigate the effects of the HA reinforcement weight fraction and morphology on the architecture and compressive mechanical properties. All scaffolds exhibited a highly elongated linear pore structure containing 90%-96% porosity, which decreased with increased HA content, and a pore width of ∼50 μm. HA reinforcement resulted in up to a ten-fold increase in compressive modulus at high reinforcement levels (∼200 kPa at 1:4 collagen:HA by weight) compared to scaffolds with no reinforcement or low reinforcement levels (∼20 kPa at 1:1 collagen:HA by weight). This effect could not be explained by the concomitant decrease in the scaffold porosity (from 95% to 90%) with HA reinforcement, which could only account ...Continue Reading

References

Jul 1, 1982·Calcified Tissue International·J Black, R U Mattson
Jul 1, 1995·Journal of Biomedical Materials Research·K S TenHuisenP W Brown
Jul 29, 1998·Medical Engineering & Physics·J Y RhoP Zioupos
Apr 11, 2000·Journal of Biomedical Materials Research·C DuK de Groot
Sep 5, 2002·Journal of Biomedical Materials Research·Soichiro ItohKenichi Shinomiya
Oct 21, 2003·Journal of Biomedical Materials Research. Part a·Anna TampieriGiuseppe Falini
Nov 13, 2003·Journal of Biomedical Materials Research. Part a·Ryan K RoederCharles H Turner
Nov 15, 2003·Biomaterials·Fergal J O'BrienLorna Gibson
Jul 28, 2004·Biomaterials·F J O'BrienL J Gibson
Apr 30, 2005·Biomaterials·Vassilis Karageorgiou, David Kaplan
Jun 13, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Shunji YunokiJunzo Tanaka
Feb 27, 2007·Journal of Materials Science. Materials in Medicine·Denys A WahlJan T Czernuszka
Mar 3, 2007·The Journal of Bone and Joint Surgery. American Volume·William G De LongTracy Watson
Mar 14, 2007·Acta Biomaterialia·Brendan A HarleyLorna J Gibson
Apr 24, 2008·Journal of Biomedical Materials Research. Part a·Matthew G HaughFergal J O'Brien
May 27, 2008·Journal of Biomechanics·Peter ZiouposJohn R Hutchinson
Jan 31, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Amir A Al-MunajjedFergal J O'Brien
Jul 25, 2009·Journal of the Mechanical Behavior of Biomedical Materials·Amir A Al-Munajjed, Fergal J O'Brien
Jan 22, 2010·Journal of Materials Science. Materials in Medicine·Gráinne M CunniffeFergal J O'Brien
Aug 10, 2010·Journal of Biomedical Materials Research. Part a·Gemma L JonesSarah H Cartmell

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Citations

Jun 14, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Matthew A SoicherDavid P Fyhrie
Aug 29, 2013·BioMed Research International·Marcello PiliaMark Appleford
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Jianhua WangQiqing Zhang
Aug 8, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Anne-Marie HaaparantaMinna Kellomäki
Sep 26, 2012·Journal of Biomedical Materials Research. Part a·Sandra C RodriguesFernando J Monteiro
Feb 18, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Pradipta BanerjeeC Shanthi
May 15, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Zahra MohammadiFariba Rasouli-Disfani
Jun 22, 2016·Journal of Biomedical Materials Research. Part a·Salim A Ghodbane, Michael G Dunn
Sep 8, 2017·The Journal of Physiological Sciences : JPS·Majid SalehiJafar Ai
Nov 21, 2015·Biomedical Materials·Mohan VedhanayagamKalarical Janardhanan Sreeram
Apr 24, 2020·Frontiers in Bioengineering and Biotechnology·Annalisa TirellaNicola Tirelli
May 26, 2018·Bulletin of Experimental Biology and Medicine·K N BardakovaR K Chailakhyan
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Dibakar MondalThomas L Willett
Dec 4, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Anabela VeigaAna L Oliveira

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