Effects of hydroxytyrosol and hydroxytyrosol acetate administration to rats on platelet function compared to acetylsalicylic acid

Journal of Agricultural and Food Chemistry
José Antonio González-CorreaJosé Pedro de la Cruz

Abstract

Virgin olive oil (VOO) contains the polyphenols hydroxytyrosol (HT) and hydroxytyrosol acetate (HT-AC). This study investigated the antiplatelet effect of HT and HT-AC in healthy rats and compared their effects to acetylsalicylic acid (ASA). All compounds were administered orally for 7 days. HT and HT-AC inhibited platelet aggregation in whole blood, with a 50% inhibitory dose (ID50) of 48.25 mg/kg per day for HT, 16.05 mg/kg per day for HT-AC, and 2.42 mg/kg per day for ASA. Platelet synthesis of thromboxane B2 was inhibited by up to 30% by HT and 37% by HT-AC; the ID50 of this effect for ASA was 1.09 mg/kg per day. Vascular prostacyclin production was inhibited by up to 27.5% by HT and 32% by HT-AC; the ID50 of this effect for ASA was 6.75 mg/kg per day. Vascular nitric oxide production was increased by up to 34.2% by HT, 66% by HT-AC, and 64% by ASA. We conclude that HT and HT-AC administered orally inhibited platelet aggregation in rats and that a decrease in thromboxane synthesis along with an increase in nitric oxide production contributed to this effect.

References

Nov 8, 1984·The New England Journal of Medicine·A K Pedersen, G A FitzGerald
Dec 20, 1999·Journal of Agricultural and Food Chemistry·M BrenesA Garrido
Jun 14, 2000·European Journal of Pharmacology·J P De La CruzF Sánchez de la Cuesta
Dec 13, 2000·Thrombosis Research·J P De La CruzF S de la Cuesta
Jun 13, 2002·Critical Reviews in Food Science and Nutrition·Francesco Visioli, Claudio Galli
Jul 31, 2003·The Journal of Nutrition·Giuseppina I TognaMarcella Guiso
Jul 31, 2003·The Journal of Nutrition·Francesco VisioliDonatella Caruso
Nov 1, 2003·Thrombosis Research·Maria MadajkaTadeusz Malinski
Nov 13, 2003·Journal of Agricultural and Food Chemistry·Raquel MateosArturo Cert
Feb 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margaret M TarpeyMatthew B Grisham
Apr 28, 2006·Journal of Agricultural and Food Chemistry·Mario Dell'AgliDonatella Caruso
Jun 14, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P PignatelliF Violi
Feb 27, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·María-Isabel Covas
Oct 4, 2007·Molecular Nutrition & Food Research·Maria Annunziata CarluccioRaffaele De Caterina
Oct 12, 2007·The British Journal of Nutrition·Mario Dell'AgliEnrica Bosisio

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Citations

Aug 30, 2011·European Journal of Nutrition·Susana Sánchez-FidalgoC Alarcón de la Lastra
Sep 24, 2010·Applied Biochemistry and Biotechnology·Zouhaier BouallaguiSami Sayadi
Dec 9, 2010·The British Journal of Nutrition·Miguel Vázquez-VelascoFrancisco J Sánchez-Muniz
Jul 20, 2012·Journal of Agricultural and Food Chemistry·Javier Muñoz-MarínJosé Antonio González-Correa
May 16, 2012·European Journal of Nutrition·J J ReyesJ A Gonzalez-Correa
Apr 27, 2010·Nutrition Reviews·Sergio Granados-PrincipalM Carmen Ramirez-Tortosa
Mar 2, 2013·Molecular Nutrition & Food Research·Sandra Martín-PeláezIgor Pravst
Nov 27, 2015·Environmental Science and Pollution Research International·Vincenzo TufarelliElisabetta Casalino
Aug 15, 2014·Critical Reviews in Food Science and Nutrition·Javier Delgado-ListaJose Lopez-Miranda
May 7, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Javier Muñoz-MarínJosé Antonio González-Correa
Jun 30, 2016·Journal of Agricultural and Food Chemistry·Isabella D'AntuonoAngela Cardinali
Oct 27, 2017·International Journal of Molecular Sciences·Cristina AngeloniSilvana Hrelia
May 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana Karković MarkovićCvijeta Jakobušić Brala
Jan 1, 2014·Frontiers in Nutrition·Cristina Vilaplana-PérezAngel Gil-Izquierdo
Nov 8, 2011·Journal of the American College of Surgeons·Alfredo C CordovaBauer E Sumpio

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