Effects of hyperbaric oxygen therapy on rat facial skin

Human & Experimental Toxicology
B SulaE Deveci

Abstract

We used immunohistochemistry to investigate the histopathologic effects of hyperbaric oxygen (HBO) on the facial skin of rats. Rats in the HBO group (n = 6) were placed in a 20 L HBO chamber at 2.5 atmospheres absolute at 25-26°C with 100% oxygen for 90 min/day for 7 days. Following euthanasia, sections of facial skin were removed for examination. Epidermal hyperplasia and degeneration, basal-cell hypertrophy, subepithelial fibrosis, and increased connective tissue were observed in the HBO group. E-cadherin expression was reduced in the epidermis, hair follicles, and sebaceous glands in HBO-treated rats relative to control animals. HBO treatment was associated with vimentin immunoreactivity in fibroblasts, endothelial cells, and the bulbus pilorum of a subset of hair follicles. It also resulted in increased type IV collagen expression within the connective tissue in the hair follicles and sebaceous glands. The HBO group demonstrated epidermal hyperplasia and degeneration, basal-cell hypertrophy, and subepithelial fibrosis. In addition, HBO decreased E-cadherin expression, which suggests that HBO may impair intracellular adhesion. Expression of vimentin and type IV collagen was also observed in the dermis. Increased connective t...Continue Reading

References

Oct 23, 1997·Anatomia, histologia, embryologia·S V BavdekG Fazarinc
Jul 4, 1998·Cancer Letters·A SchwentkerS R Thom
Jun 23, 2004·QJM : Monthly Journal of the Association of Physicians·A L Gill, C N A Bell
Jan 26, 2006·The British Journal of Dermatology·W-H JuanC-H Yang
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irene H HeijinkEdo Vellenga
Mar 14, 2008·The Journal of Investigative Dermatology·Qixu ZhangLisa J Gould
Mar 7, 2012·North American Journal of Medical Sciences·Ana Maria Abreu-Velez, Michael S Howard

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Citations

Sep 2, 2017·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Alicia Galindo-FerreiroSilvana A Schellini

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Methods Mentioned

BETA
light microscopy

Software Mentioned

Statistical Package for the Social Sciences

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