Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses

Veterinary Anaesthesia and Analgesia
Robert BrosnanAndré Escobar

Abstract

To test the hypothesis that hypercapnic hyperpnea produced using endotracheal insufflation with 5-10% CO(2) in oxygen could be used to shorten anesthetic recovery time in horses, and that recovery from sevoflurane would be faster than from isoflurane. Randomized crossover study design. Eight healthy adult horses. After 2 hours' administration of constant 1.2 times MAC isoflurane or sevoflurane, horses were disconnected from the anesthetic circuit and administered 0, 5, or 10% CO(2) in balance O(2) via endotracheal tube insufflation. End-tidal gas samples were collected to measure anesthetic washout kinetics, and arterial and venous blood samples were collected to measure respiratory gas partial pressures. Horses recovered in padded stalls without assistance, and each recovery was videotaped and evaluated by reviewers who were blinded to the anesthetic agent and insufflation treatment used. Compared to isoflurane, sevoflurane caused greater hypoventilation and was associated with longer times until standing recovery. CO(2) insufflation significantly decreased anesthetic recovery time compared to insufflation with O(2) alone without significantly increasing PaCO(2) . Pharmacokinetic parameters during recovery from isoflurane with...Continue Reading

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Citations

Feb 26, 2014·American Journal of Veterinary Research·Ashley J WieseLinda S Barter
Mar 19, 2013·The Veterinary Clinics of North America. Equine Practice·Robert J Brosnan
Feb 25, 2015·American Journal of Veterinary Research·Ana C S ValenteAlonso G P Guedes
Aug 5, 2017·Equine Veterinary Journal·J P PlattA E Watts
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Miguel Gozalo-Marcilla, Simone Katja Ringer
Aug 8, 2021·Animals : an Open Access Journal From MDPI·Elżbieta StefanikBernard Turek

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