Effects of hyperchloremia on renal recovery in critically ill children with acute kidney injury.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Matthew F BarhightKatja M Gist

Abstract

Serum chloride derangements are associated with poor clinical outcomes, including acute kidney injury (AKI) and mortality. We sought to determine the association between persistent hyperchloremia and renal recovery in critically ill children with AKI. We performed a retrospective cohort study of all patients with day 2 AKI admitted to a large academic pediatric intensive care unit from January 2014 to December 2015. After applying exclusion criteria, 348 patients were categorized as (1) hyperchloremia on both day 2 and day 7 (PersistentCl), (2) hyperchloremia on day 2 with normochloremia on day 7 (RecoveredCl), (3) normochloremia on day 2 with hyperchloremia on day 7 (DelayedCl), and (4) no hyperchloremia on day 2 nor day 7 (NormalCl). Hyperchloremia was defined as ≥ 110 mEq/L. The primary outcome was renal recovery on day 7, defined as the absence of AKI criteria. Secondary outcomes included discharge renal recovery, mortality, duration of mechanical ventilation, and hospital length of stay. Day 7 renal recovery rates for PersistentCl, RecoveredCl, DelayedCl, and NormalCl were 37%, 66%, 71%, and 52% respectively. PersistentCl had lower odds of day 7 renal recovery (aOR = 0.29; 95% CI, 0.14 to 0.60; p = 0.0009), lower odds of d...Continue Reading

References

Mar 1, 1983·The Journal of Clinical Investigation·C S Wilcox
May 1, 1996·Critical Care Medicine·M M PollackU E Ruttimann
Apr 18, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Michael ZappitelliStuart L Goldstein
Jan 23, 2009·Journal of the American Society of Nephrology : JASN·George J SchwartzSusan L Furth
Jan 1, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Scott M SutherlandStuart L Goldstein
Dec 31, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cherry MammenDouglas G Matsell
Aug 15, 2012·Nephron. Clinical Practice·Arif Khwaja
Jul 15, 2015·Critical Care Medicine·Javier A NeyraUNKNOWN Acute Kidney Injury in Critical Illness Study Group
Mar 14, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seth A HollanderScott M Sutherland
May 11, 2016·Journal of Thoracic Disease·Charat ThongprayoonKianoush Kashani
Sep 17, 2016·American Journal of Respiratory and Critical Care Medicine·John A KellumLakhmir S Chawla
Oct 8, 2016·Critical Care : the Official Journal of the Critical Care Forum·Bandarn SuetrongKeith R Walley
Dec 14, 2016·The New England Journal of Medicine·Ahmad KaddourahUNKNOWN AWARE Investigators
Feb 28, 2017·Nature Reviews. Nephrology·Lakhmir S ChawlaUNKNOWN Acute Disease Quality Initiative Workgroup 16.
May 4, 2017·Intensive Care Medicine·L G ForniM Joannidis
Feb 3, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Erin K StensonHector R Wong
Feb 7, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Matthew F BarhightKatja M Gist
Oct 17, 2018·Intensive Care Medicine·Erin K StensonNick Anas

❮ Previous
Next ❯

Citations

Feb 20, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Chetan Khare, Avantika Gupta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.