PMID: 18200365Jan 18, 2008Paper

Effects of hyperoxia on Wistar rat lungs

Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Samuel Dos Santos ValençaLuís Cristóvão Porto

Abstract

To study the effects of short-term exposure to high oxygen concentrations (hyperoxia) on Wistar rat lungs. Animals were divided into three groups exposed to hyperoxia for 10', 30' and 90' (O10', O30', O90', respectively), together with a control group (exposed to room air). The animals were sacrificed 24 h after exposure. Bronchoalveolar lavage was performed, and the lungs were removed for histological and stereological analysis. In the O10', O30', and O90' groups, respectively and in comparison with the controls, we observed an increase in the numbers of macrophages (2169.9 +/- 118.0, 1560.5 +/- 107.0, and 1467.6 +/- 39.0 vs. 781.3 +/- 78.3) and neutrophils (396.3 +/- 35.4, 338.4 +/- 17.3, and 388.7 +/- 11.7 vs. 61.6 +/- 4.2), concomitant with an increase in oxidative damage (143.0 +/- 7.8%, 180.4 +/- 5.6%, and 235.0 +/- 13.7 vs. 100.6 +/- 1.7%). The histological and stereological analyses revealed normal alveoli and alveolar septa in the controls (83.51 +/- 1.20% and 15 +/- 1.21%), in the O10' group (81.32 +/- 0.51% and 16.64 +/- 0.70%), and in the O30' group (78.75 +/- 0.54% and 17.73 +/- 0.26%). However, in the O90' group, inflammatory cell infiltration was observed in the alveoli and alveolar septa. Red blood cells extrava...Continue Reading

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Citations

Dec 27, 2016·Oxidative Medicine and Cellular Longevity·Nicia Pedreira SoaresFrank Silva Bezerra
Nov 10, 2009·Experimental Lung Research·Akinori NagatoSamuel Santos Valenca
Jul 24, 2013·Inhalation Toxicology·R HowdenY Mishina
Jun 17, 2010·Annals of Biomedical Engineering·Madhavi RamakrishnaSaid H Audi
Nov 18, 2020·Respiratory Physiology & Neurobiology·Matheus Rocha AlmeidaFrank Silva Bezerra

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