Effects of hyperoxic ventilation on hemodilution-induced changes in anesthetized dogs

Transfusion
O P HablerK F Messmer

Abstract

In subjects who have undergone acute preoperative normovolemic hemodilution (ANH), intraoperative hemorrhage is generally treated by immediate return of autologous blood collected during ANH. Simply increasing blood oxygen content by hyperoxic ventilation (HV, inspiratory fraction [FIO2] 1.0) might compensate for the acute anemia, allow further ANH, and delay onset of autologous blood return. This study 1) evaluated the effects of HV (FIO2 1.0) upon ANH to a hemoglobin (Hb) concentration of 7 g per dL in anesthetized dogs ventilated with room air and 2) compared the effects of subsequent profound ANH (Hb, 3 g/dL) with and without an intravenous perfluorocarbon emulsion (perflubron 60% wt/vol) versus those of autologous red cell transfusion. The results of the entire study are presented in two parts. Organ tissue oxygenation was assessed in skeletal muscle and liver, and systemic oxygenation status was evaluated. Myocardial contractility was deduced from left ventricular pressure-volume relationship. Seven of 22 dogs underwent further hemodilution while breathing 100-percent O2, for a determination of the Hb concentration at which HV-induced effects were abolished. HV completely reversed the ANH-induced increase in cardiac index...Continue Reading

Citations

Apr 5, 2011·Der Anaesthesist·J Meier, O Habler
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Aug 31, 2002·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Uwe Kreimeier, Konrad Messmer
Oct 20, 2010·Journal of Neurotrauma·Garth H UtterJ Paul Muizelaar
Mar 6, 2003·Vox Sanguinis·Donat R Spahn
Aug 12, 2010·Artificial Organs·Camila Irene Castro, Juan Carlos Briceno
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Apr 18, 2013·Best Practice & Research. Clinical Anaesthesiology·Jens Meier, Hans Gombotz
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