Effects of hyperpolypharmacy and potentially inappropriate medications (PIMs) on functional decline in older patients discharged from acute care hospitals

Archives of Gerontology and Geriatrics
Paolo FabbiettiMirko Di Rosa

Abstract

To comparatively investigate the effects of hyperpolypharmacy and potentially inappropriate medications (PIMs) on functional decline in older patients after hospital discharge. Our series consisted of 733 patients aged ≥65 consecutively enrolled in a multicenter observational longitudinal study. PIMs were defined on the basis of updated versions of Beers and STOPP criteria. The occurrence of functional decline was defined as the loss of independency in at least 1 basic activity of daily living (BADL) from discharge through 3-month follow-up visit. After adjusting for several potential confounders, hyperpolypharmacy (OR = 2.20; 95%CI = 1.11-4.37) and Beers violations (OR = 1.99; 95%CI = 1.17-3.49) were significantly associated with functional decline, while STOPP (OR = 1.10; 95%CI = 0.64-1.88) and combined Beers + STOPP violations (OR = 1.72; 95%CI = 0.97-3.05) were not. In logistic regression models simultaneously including both hyperpolypharmacy and PIMs, hyperpolypharmacy was always associated with functional decline (OR = 1.98; 95%CI = 1.0-3.97 in the model including Beers violations; OR = 2.19; 95%CI = 1.11-4.35 in the model including STOPP violations; OR = 2.04; 95%CI = 1.02-4.06 in the model including combined Beers and S...Continue Reading

Citations

Jun 10, 2020·Pharmacoepidemiology and Drug Safety·Mengyuan FuDennis Ross-Degnan
Jul 22, 2020·Geriatrics & Gerontology International·Eiji Kose, Hidetaka Wakabayashi
Jun 27, 2019·Journal of General Internal Medicine·Andreas KatsimprisKonstantinos Volaklis
Jul 30, 2020·PM & R : the Journal of Injury, Function, and Rehabilitation·Makiko YamaokaRyo Momosaki
Jun 5, 2021·European Journal of Hospital Pharmacy. Science and Practice·Richard S BourneDaniele C Bryden
Sep 13, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Divya BhargavaDaniel J Weisdorf

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