PMID: 8458642Apr 1, 1993Paper

Effects of hypertension and aging on coronary arteriolar density

Hypertension
J C VitulloP Wicker

Abstract

Coronary reserve has been shown repeatedly to be depressed in hypertension and aging. The underlying mechanisms remain elusive, but structural alterations of the coronary vasculature have been implicated. In this study, we measured maximal coronary dilator capacity and structural characteristics relevant to coronary resistance in aging normotensive (Wistar-Kyoto, n = 22) and spontaneously hypertensive rat (SHR) strains (n = 25) at 1.5, 4, 11, 16, and 22 months of age. Coronary flow measurements, using radiolabeled microspheres, demonstrated a significant (p < 0.01) hypertension- and age-related decline in maximal coronary dilator capacity. After flow measurements, vascular dimensions and arteriolar density were obtained from 1-micron sections prepared from perfusion-fixed hearts. A total of 10,012 arterioles were analyzed, 4,820 in hypertensive and 5,192 in normotensive rats. There was an 18-28% reduction in arteriolar density in hypertensive rats that specifically affected the terminal arteriolar bed at 1.5-11 months. However, the decrement in arteriolar density stabilized at 10% and 6% in 16- and 22-month-old hypertensive rats, respectively. Arteriolar density was not affected by aging. In both strains, there was a significan...Continue Reading

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Citations

Oct 12, 2000·Nihon rinsho. Japanese journal of clinical medicine·Y SaitoR Nagai
Jun 8, 2001·Journal of Cardiovascular Pharmacology·G Ertl, K Hu
Sep 24, 1998·Journal of Hypertension·B E StrauerM Kelm
Dec 15, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Amanda J LeBlanc, James B Hoying
Sep 17, 2013·The Journal of Sexual Medicine·Karl A BeetsonSelim Cellek
Mar 1, 1996·The Annals of Thoracic Surgery·P G BurnsS Levitsky
Mar 26, 2013·Mechanisms of Ageing and Development·Edina A WapplerGyörgy L Nádasy
Feb 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·C A CaldaroneS Levitsky
Jul 7, 2000·Pharmacology & Therapeutics·T KomaruK Shirato

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