PMID: 7372354Jan 1, 1980Paper

Effects of hypertension and its reversal on aortic intima lesions of the rat

Hypertension
C C HaudenschildA V Chobanian

Abstract

A combined transmission (TEM) and scanning (SEM) electron microscopic study was performed on aortae of deoxycorticosterone-salt (DOC-salt)-treated rats and spontaneously hypertensive rats (SHR) to compare the effects of hypertension as well as its reversal on the aortic intima. To best reproduce the in vivo state of the vasculature, rats were perfusion-fixed at pressures corrected for each individual animal (30 mm Hg below measured systolic pressure). The intimal alterations were focal and thus were best appreciated with the combined use of SEM and TEM. Qualitatively, both models of hypertension showed similar intimal changes, which consisted of subintimal thickening due to an accumulation of both extracellular material and cells. Subendothelial cells with a morphology indicating a blood-borne origin were present simultaneously with cells derived from the vessel wall. The increased subendothelial extracellular material included precipitated plasma proteins, reticulated basement membrane, collagen fibers, and fragments of elastin. Increase in the height of endothelial cells with distortion of nuclear shape was prominent. Withdrawal of DOC-salt combined with low-salt diet for 11 weeks did not result in a discernible regression of...Continue Reading

References

Jan 7, 1978·Lancet·G BerglundJ Wikstrand
Oct 1, 1978·Circulation Research·P BrecherA V Chobanian
Aug 1, 1978·Experimental and Molecular Pathology·H G Greditzer, V W Fischer
Nov 1, 1976·The American Journal of Medicine·R P Ames, P Hill
Jun 25, 1976·Science·J M Clark, S Glagov
Jul 15, 1972·Experientia·C HaudenschildA Studer
Aug 15, 1974·The New England Journal of Medicine·J Taguchi, E D Freis
Jul 1, 1970·Circulation Research·M L ArmstrongW E Connor
Sep 1, 1969·The Journal of Cell Biology·G MajnoM Leventhal
Jan 1, 1967·Circulation Research·J de ChamplainJ Axelrod
Oct 1, 1954·The Journal of Clinical Investigation·L TOBIAN, J BINION
Dec 1, 1961·The American Journal of Cardiology·E D FREIS
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI

❮ Previous
Next ❯

Citations

Nov 1, 1983·Progress in Cardiovascular Diseases·A V Chobanian
Jan 1, 1996·Journal of the American College of Cardiology·A Nitenberg, I Antony
Aug 1, 1997·Pharmacology & Therapeutics·J Marín, M A Rodríguez-Martínez
Feb 1, 1983·Journal of the American College of Cardiology·J A Spittell
Oct 1, 1996·Journal of the American College of Cardiology·J FrielingsdorfO M Hess
Jul 1, 1991·The Australian and New Zealand Journal of Surgery·M Tennant, J K McGeachie
Jul 18, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ludovit PaulisFedor Simko
Nov 1, 1987·Journal of Neurosurgery·P D DernbachJ F Cusick
Apr 1, 1989·The Journal of Clinical Investigation·R SarzaniA V Chobanian
Sep 1, 1988·The Journal of Clinical Investigation·J N WilcoxD Gordon
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R SarzaniP Brecher
Apr 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·S H DondersJ W Van Wersch
Jan 1, 1991·Annals of the New York Academy of Sciences·S D FowlerD N Xenachis
Feb 1, 1987·Journal of Vascular Surgery·J O MenzoianA V Chobanian
Dec 14, 1987·The American Journal of Cardiology·A V Chobanian
Dec 14, 1987·The American Journal of Cardiology·M J Peach, A L Loeb
Dec 1, 1995·Atherosclerosis·S M SchwartzC E Murry
Aug 1, 1984·Experimental and Molecular Pathology·A V ChobanianC C Haudenschild
Dec 30, 1993·The American Journal of Cardiology·W A Hsueh, P W Anderson
Dec 1, 1986·Experimental and Molecular Pathology·J O MenzoianA V Chobanian
Dec 1, 1986·Experimental and Molecular Pathology·M C KowalaG Majno
Nov 1, 1988·The American Journal of Medicine·M P SambhiH M Perry
May 1, 1993·Circulation·T F Lüscher, W E Haefeli
May 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M F Prescott, K R Müller
May 1, 1985·Hypertension·C C HaudenschildA V Chobanian
May 1, 1981·Hypertension·C C HaudenschildA V Chobanian
Jun 1, 1986·Hypertension·A H LichtensteinA V Chobanian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.