PMID: 8958985Nov 18, 1996Paper

Effects of hypertension and propranolol upon aneurysm expansion in the Anidjar/Dobrin aneurysm model

Annals of the New York Academy of Sciences
M A RicciD B Pilcher

Abstract

Propranolol has been suggested to slow aortic aneurysm (AAA) expansion by a mechanism independent of simple blood pressure (BP) reduction. To investigate this hypothesis, we designed a series of experiments to examine the effects of hypertension and propranolol upon AAA expansion. Using an established animal model, we induced AAA in normotensive and genetically hypertensive rats by perfusion of the isolated infrarenal aorta with elastase for two hours. Systolic tail BP was monitored with a plethysmograph. AAA size was measured directly with a micrometer on postoperative days 7 and 14. All data are expressed as the mean +/- standard deviation (SD). BP (mmHg) was significantly higher in hypertensive rats: 164 +/- 15 versus 119 +/- 7 (p < 0.001). AAA were also significantly larger in hypertensive rats with a mean expansion rate (mm/day) nearly twice that of normotensive animals: 0.13 +/- 0.09 versus 0.07 +/- 0.03. In a second series of animals, propranolol treatment was compared to placebo. In those animals, hypertensive propranolol-treated rats had significantly smaller AAA than placebo-treated controls (p < 0.05). There was no difference in normotensive animals but these rats had an unexplained paradoxical rise in BP with treatm...Continue Reading

References

Nov 23, 1976·The American Journal of Cardiology·W Hollander
Sep 1, 1990·Circulation·S AnidjarJ B Michel
Aug 1, 1989·The Surgical Clinics of North America·P B Dobrin
Jun 1, 1988·The Journal of Surgical Research·C BrophyM D Tilson
Aug 1, 1994·Journal of Vascular Surgery·J M SlaibyD B Pilcher
May 1, 1993·The Journal of Surgical Research·G R GadowskiD B Pilcher
Mar 1, 1993·Annals of Vascular Surgery·R J FowlR F Kempczinski

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Citations

Aug 24, 2000·Surgery Today·T YamaguchiT Misaki
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Lisa A CassisAlan Daugherty
Oct 29, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Koji KurosawaDai Yamanouchi
Nov 15, 2002·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Harpaul S FloraMohan Adiseshiah
Jul 2, 1999·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·I J FranklinJ T Powell
Feb 13, 2001·The Journal of Surgical Research·T YamaguchiT Misaki
Sep 16, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Jonathan GolledgePaul Norman
Jan 18, 2014·American Journal of Public Health·Patricia A McDanielRuth E Malone

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