PMID: 3762663Aug 1, 1986Paper

Effects of hyperthermia on phagocytosis and intracellular killing of Sporothrix schenckii by polymorphonuclear leukocytes

Mycopathologia
M Hiruma, S Kagawa

Abstract

The effects of hyperthermia on phagocytosis and killing of Sporothrix schenckii by polymorphonuclear leukocytes (PMNs) were investigated in order to clarify the mechanism of local thermotherapy for sporotrichosis. Yeast cells of S. schenckii, PMNs and serum were incubated at 37 degrees C or 40 degrees C for 2 or 4 hours. Rate of phagocytosis and killing rate (rate of germination) were estimated, and their processes were observed by transmission electron microscopy. There was no effect of hyperthermia on the phagocytosis rate, but the killing rate increased significantly at 40 degrees C. Electron microscopic examination showed an increase of granularity in the yeast cytoplasm, elongation and fragmentation of the cell membrane. The ultrastructural changes were basically identical under both temperatures, but the degree of these changes was higher at 40 degrees C than at 37 degrees C. Although both intact and degenerated yeasts were found in the same conditions, their transient forms were few, suggesting that the PMN-killing process was completed promptly.

References

Nov 1, 1979·The Journal of Infectious Diseases·K M CunninghamE R Rhoades
Jun 1, 1969·Journal of Bacteriology·R I Lehrer, M J Cline
Dec 1, 1983·Mycopathologia·M Hiruma, S Kagawa
Apr 1, 1984·Journal of the American Academy of Dermatology·H TagamiS Urano-Suehisa
Feb 1, 1983·Infection and Immunity·L M OdaL R Travassos

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Citations

May 1, 1996·International Journal of Antimicrobial Agents·D V PechkovskyO M Zalutskaya
May 20, 2003·Infectious Disease Clinics of North America·Flavio Queiroz-TellesJohn R Graybill
Nov 24, 2011·Cutaneous and Ocular Toxicology·Sedef Bayata, Aylin Türel Ermertcan
May 15, 2010·Journal of the American Academy of Dermatology·Christy Badgwell DohertyTheodore Rosen
Sep 3, 2005·Immunological Investigations·Julie R OstbergJulie A Lanphere
Sep 12, 2013·Fungal Genetics and Biology : FG & B·Gregory M Gauthier, Nancy P Keller
Mar 5, 2013·PloS One·Nrusingh P MohapatraJohn S Gunn
May 28, 2004·Perfusion·Robert C GroomUNKNOWN Northern New England Cardiovascular Disease Study Group
Jul 1, 1987·Mykosen·M HirumaS Kagawa
Feb 16, 2010·The Veterinary Record·C O HonseT M P Schubach
Oct 1, 1996·Clinical Microbiology Reviews·L H HoganS M Levitz

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