PMID: 6403734Jan 1, 1983Paper

Effects of hypertonic glucose on the rates of plasma clearance and CO2 production of intravenously administered intralipid emulsion in dogs

JPEN. Journal of Parenteral and Enteral Nutrition
W J Chen

Abstract

Simultaneous infusion of glucose and Intralipid was carried out on dogs to evaluate the effect of glucose on utilization of the fat emulsion. For control experiments, normal saline was used in place of glucose. Results of these studies revealed that clearance of Intralipid and also of triglyceride and free fatty acid (FFA) from the plasma did not differ between the dogs receiving glucose and those receiving saline infusion. The rates of Intralipid clearance were 0.049 +/- 0.003 and 0.047 +/- 0.003 per minute (n = 16), respectively. Study with radioactive [14C]Intralipid also gave similar rates of 14C clearance from the plasma, 0.037 +/- 0.003 and 0.040 +/- 0.003 per minute (n = 4), respectively for the two groups. These suggested that clearance of Intralipid from the plasma was not affected by glucose. However, data on expired 14CO2 revealed that oxidation of the fat, which yielded CO2 as end product, was inhibited by glucose. The amount of 14CO2 expired in 2 hours was 10.4 +/- 1.4% for the saline group, which was significantly reduced to 3.0 +/- 0.4% (n = 4; p less than 0.01) for the glucose group. In each group, CO2 production was much delayed as compared to fat clearance from the plasma. Thus, the rate of clearance of Intral...Continue Reading

References

Oct 1, 1978·The Surgical Clinics of North America·A Wretlind
Jun 1, 1973·The American Journal of Clinical Nutrition·J EckartH Schaaf
Apr 11, 1969·Analytical Biochemistry·A Zlatkis, B Zak
May 1, 1973·Annals of Surgery·G L BlackburnT E Hensle
May 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·L A Carlson, S Rössner
Nov 1, 1966·The Journal of Clinical Investigation·G F CahillD M Kipnis
Nov 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·C L SkutchesG A Reichard
May 1, 1981·JPEN. Journal of Parenteral and Enteral Nutrition·G J JesmokG Walsh
May 1, 1981·JPEN. Journal of Parenteral and Enteral Nutrition·A Wretlind
Jul 1, 1963·The Biochemical Journal·C N HALES, P J RANDLE
Dec 1, 1964·Acta Physiologica Scandinavica·P BELFRAGET OLIVECRONA
Jan 1, 1965·The American Journal of Clinical Nutrition·L W KINSELLK IMAICHI

❮ Previous
Next ❯

Citations

Jan 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·W J Chen
Sep 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·L G YamamotoJ E Witek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.