Effects of hypertonic saline (7.5%) on extracellular fluid volumes compared with normal saline (0.9%) and 6% hydroxyethyl starch after aortocoronary bypass graft surgery

Journal of Cardiothoracic and Vascular Anesthesia
K JärveläT Kööbi

Abstract

To compare the effects of hypertonic (7.5%) saline (HS), normal (0.9%) saline (NS), and 6% hydroxyethyl starch (HES) on extracellular fluid volumes in the early postoperative period after cardiopulmonary bypass. A prospective, randomized, double-blind study. University teaching hospital. Forty-eight patients scheduled for elective coronary artery bypass graft surgery. Patients were randomly allocated to receive 4 mL/kg of HS, NS, or HES during 30 minutes when volume loading was needed during the postoperative rewarming period in the intensive care unit. Plasma volume was measured using a dilution of iodine-125-labeled human serum albumin. Extracellular water and cardiac output were measured by whole-body impedance cardiography. Plasma volume had increased by 19 +/- 7% in the HS group and by 10 +/- 3% in the NS group (p = 0.001) at the end of the study fluid infusion. After 1-hour follow-up time, the plasma volume increase was greatest (23 +/- 8%) in the group receiving HES (p < 0.001). The increase of extracellular water was greater than the infused volume in the HS and HES groups at the end of the infusion. One-hour diuresis after the study infusion was greater in the HS group (536 +/- 280 mL) than in the NS (267 +/- 154 mL, p...Continue Reading

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Citations

Mar 28, 2008·Surgical Infections·Michalis P CharalambousPamela A Lipsett
Dec 6, 2014·Critical Care : the Official Journal of the Critical Care Forum·Matthias JacobAndrea Kurz
Mar 16, 2017·Archivos de cardiología de México·Luis Horacio Atehortúa-LópezFabian Jaimes
Aug 22, 2007·Perfusion·Edmundas SirvinskasDalia Adukauskiene
Mar 24, 2005·World Journal of Gastroenterology : WJG·Yong-Sheng ShaoZhuo-Yong Quan
Jul 22, 2004·The Cochrane Database of Systematic Reviews·F BunnE Akpa
Feb 12, 2014·Current Opinion in Anaesthesiology·Giovanni Mariscalco, Francesco Musumeci
Apr 5, 2016·European Journal of Anaesthesiology·Gernot MarxMichaela Eikermann
Mar 1, 2005·Journal of the Royal Army Medical Corps·J E Smith, M J Hall
May 15, 2012·The Journal of Thoracic and Cardiovascular Surgery·Roberta J NavickisMahlon M Wilkes
Jun 1, 2006·Journal of the American College of Surgeons·David S KauvarThomas J Walters

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