PMID: 7528584Oct 1, 1994Paper

Effects of hypertonic saline hydroxyethyl starch solution on collagen-induced platelet aggregation and ATP secretion

Infusionstherapie und Transfusionsmedizin
R SchererW J Kox

Abstract

The purpose of this study was to investigate the effect of hypertonic (NaCl 7.5%) hydroxyethyl starch (HES 6%, molecular weight 200,000) (HHES) as used for small-volume resuscitation on global coagulation parameters and platelet function. Randomized, controlled clinical trial. Intraoperative volume loading after induction of general anesthesia. 27 consecutive patients [mean age 59 (22-76) years, mean body weight 69.8 (46-98) kg] undergoing abdominal surgery were studied. Global coagulation tests (aPTT: activated partial thromboplastin time; PT: prothrombin time; platelet count; thrombelastography: TEG), platelet aggregation and ATP release were measured before and 10 min after the application of 4 ml.kg-1 of HHES (study group H, n = 14) or HES (control group C, n = 13). The aPTT was prolonged and platelet count was significantly reduced in both study groups. In contrast to the HES group, clot formation time in the TEG was significantly prolonged and the maximum amplitude was reduced in the HHES group. Furthermore, platelet aggregation was significantly slowed down, whereas ATP release significantly increased in the HHES group. The changes in global coagulation parameters can be explained by dilutional effects of the infused sol...Continue Reading

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