Effects of hypertonic saline, mannitol, and urea with regard to absorption and rebound filtration in cat skeletal muscle

Critical Care Medicine
Staffan HolbeckPer-Olof Grände

Abstract

To study the effects of the hypertonic solutions 15% mannitol, 3% and 7.5% saline, and 30% urea at clinically relevant plasma concentrations with regard to absorption and rebound effects on tissue volume in skeletal muscle. A prospective, experimental study. University laboratory. Twenty-eight anesthetized cats. The study was performed on an autoperfused and denervated cat calf muscle placed in a fluid-filled plethysmograph. Muscle volume changes and capillary filtration coefficient (reflecting capillary fluid conductivity) were measured before, during, and after intra-arterial infusion (4 mL/hr) of the hypertonic solutions. Mannitol and 3% saline have the same osmolality and were compared specifically in an attempt to distinguish osmotic effects from those specific to the compound. All solutions reduced muscle volume during the infusion (p < .05). The maximum volume reduction persisted after 2 hrs of infusion for 3% and 7.5% saline, whereas there was a tendency for volume recovery during the urea infusion and a complete recovery back to control for mannitol. After discontinuation of the infusions, the muscle volume increased for all four solutions, stabilizing at the initial control for 3% and 7.5% saline, whereas it increased...Continue Reading

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Citations

May 20, 2011·Journal of Neurosurgical Anesthesiology·Per-Olof Grände
Sep 13, 2011·Journal of Neurosurgical Anesthesiology·Per-Olof Grände
Feb 19, 2008·Shock·Miriam S Giambelluca, Oscar A Gende
Sep 8, 2012·Journal of Neurosurgical Anesthesiology·Per-Olof Grände, Bertil Romner

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