PMID: 9422434Jan 1, 1997Paper

Effects of hypertonicity on water intake in the elderly: an age-related failure

Geriatric Nephrology and Urology
M McAloon DykeK L Minaker

Abstract

Dehydration is a common clinical syndrome associated with many illnesses and treatments in the elderly. Prior studies have shown diminished sensation of thirst during water deprivation. It is currently unclear whether age-related decreases in thirst perception impair the defense against a hyperosmolar challenge. To examine the impact of water ingestion during hyperosmolality, young and old subjects were allowed free access to water during and after an intravenous infusion of 5% hypertonic saline. Cumulative water intake and serum osmolality were compared between seven healthy young (20-28 yrs) and seven healthy old (72-89 yrs) volunteers during and following a two hour hypertonic saline infusion at a rate of 0.06 mlxkg(-1) min(-1). Serum osmolality and water intake were markedly different between the two groups. In the old group, serum osmolality increased by 17 mosmol/kg above baseline despite free access to water. In contrast, serum osmolality increased to only 7 mosmol/kg above baseline in the young group and did not rise further. By ingesting water, the young were able to defend against an additional increase in serum osmolality. The young drank approximately twice that of the old during the infusion period. Healthy older i...Continue Reading

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Sep 1, 1994·Journal of the American Geriatrics Society·A D WeinbergK L Minaker

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Citations

Nov 1, 2006·Irish Journal of Medical Science·K A O'ConnorD O'Mahony
Jun 1, 2010·International Journal of Biometeorology·Maki SatoSatoshi Iwase
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·M J McKinleyM L Mathai
Jul 3, 2013·American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses·Shoshana AraiKathleen Puntillo
Dec 7, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ahmed M El-SharkawyDileep N Lobo
Jul 18, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·J Morley
May 19, 2009·Biological Research for Nursing·Claudia Chaperon
Jul 9, 2010·Advances in Chronic Kidney Disease·Lynn E SchlangerJeff M Sands

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