Effects of Hypoglycemia on Circulating Stem and Progenitor Cells in Diabetic Patients

The Journal of Clinical Endocrinology and Metabolism
Gian Paolo FadiniAngelo Avogaro

Abstract

Iatrogenic hypoglycemia is the most common acute diabetic complication, and it significantly increases morbidity. In people with diabetes, reduction in the levels of circulating stem and progenitor cells predicts adverse outcomes. To evaluate whether hypoglycemia in diabetes affects circulating stem cells and endothelial progenitor cells (EPCs). We performed an experimental hypoglycemia study (Study 1) and a case-control study (Study 2). Tertiary referral inpatient clinic. Type 1 diabetic patients (Study 1, n = 19); diabetic patients hospitalized for severe iatrogenic hypoglycemia, matched inpatient and outpatient controls (Study 2, n = 22/group). Type 1 diabetic patients underwent two in-hospital sessions of glucose monitoring during a breakfast meal with or without induction of hypoglycemia in random order. In Study 2, patients hospitalized for hypoglycemia and matched controls were compared. Circulating stem cells and EPCs were measured by flow cytometry based on the expression of CD34 and kinase insert domain receptor (KDR). In Study 1, the physiologic decline of CD34+KDR+ EPCs from 8 am to 2 pm was abolished by insulin-induced hypoglycemia in type 1 diabetic patients. In Study 2, diabetic patients hospitalized for severe i...Continue Reading

Associated Clinical Trials

Apr 12, 2016·Daniela Bruttomesso

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Citations

Aug 17, 2018·The Journal of Clinical Endocrinology and Metabolism·Benedetta Maria BonoraGian Paolo Fadini
Jun 19, 2019·The Journal of Clinical Endocrinology and Metabolism·Gian Paolo FadiniAngelo Avogaro
May 6, 2020·Journal of Endocrinological Investigation·F BoscariG P Fadini

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