Abstract
1. The effects of removal of the pituitary on vas deferens contractile function were examined in young adult male rats having undergone hypophysectomy 7 days previously. Sham-operated age-matched rats served as controls. Responses to electrical field stimulation (EFS), and exogenous noradrenaline (NA) and beta, gamma-methylene ATP (beta, gamma-meATP) were tested. 2. Hypophysectomized rats lost weight over the 7 days. Body weights were 267.2 +/- 3.9 g (n = 7) in controls and 195.3 +/- 1.56 g (n = 5) with hypophysectomy. The wet weight of the vas deferens from rats with hypophysectomy, 22.8 +/- 1.8 mg (n = 5) was approximately half that of the controls, 41.3 +/- 1.2 mg (n = 7). The contractile response to KCl was smaller in hypophysectomized preparations (0.97 +/- 0.9 g, n = 5) than in controls (2.91 +/- 0.2 g, n = 7). 3. The alpha 1-adrenoceptor antagonist prazosin (1 microM) was more effective as an inhibitor of the tonic than of the twitch component of the contractile response, indicating a dominant adrenergic component. However, alpha, beta-methylene ATP was also effective at inhibiting the tonic component, indicating that ATP is also released secondarily to NA. 4. Absolute contractions to EFS of vas deferens from hypophysect...Continue Reading
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