Effects of hypoproteinemia-induced myocardial edema on left ventricular function

The American Journal of Physiology
M MiyamotoP D Myerowitz

Abstract

In previous studies, we observed left ventricular (LV) systolic and diastolic dysfunction in association with interstitial myocardial edema (IME) induced by either coronary venous hypertension (CVH) or lymphatic obstruction. In the present study, we examined the effects of myocardial edema induced by acute hypoproteinemia (HP) on LV systolic and diastolic function. We also combined the methods of HP and CVH (HP-CVH) to determine their combined effects on LV function and myocardial water content (MWC). We used a cell-saving device to lower plasma protein concentration in HP and HP-CVH groups. CVH was induced by inflating the balloon in the coronary sinus. Six control dogs were treated to sham HP. Conductance and micromanometer catheters were used to assess LV function. Contractility, as measured by preload recruitable stroke work, did not change in control or HP groups but declined significantly (14.5%) in the HP-CVH group. The time constant of isovolumic LV pressure decline (tau) increased significantly from baseline by 3 h in the HP (24.8%) and HP-CVH (27.1%) groups. The end-diastolic pressure-volume relationship (stiffness) also increased significantly from baseline by 3 h in the HP (78.6%) and HP-CVH (42.6%) groups. Total pl...Continue Reading

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Citations

Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R H StewartG A Laine
Jun 20, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Ranjeet M DongaonkarGlen A Laine
May 18, 2010·Cardiovascular Research·Ranjeet M DongaonkarGlen A Laine
Jan 8, 2014·Journal of Thoracic Imaging·Vishal SharmaBalazs Ruzsics
Dec 1, 2020·Frontiers in Veterinary Science·Randolph H Stewart

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