Effects of hypothalamic lesions on the body temperature rhythm of the golden hamster

Neuroreport
A R Osborne, R Refinetti

Abstract

The effects of electrolytic and neurotoxic lesions of the suprachiasmatic nucleus (SCN) and preoptic area (POA) of the anterior hypothalamus were studied by temperature telemetry in the golden hamster (Mesocricetus auratus) examined under two ambient temperature conditions: 24 degrees C and 6 degrees C. Although attempted lesions with microinjections of ibotenic acid proved unsuccessful, electrolytic lesions of the SCN eliminated the circadian rhythm of body temperature (CRT), indicating an active role of this nucleus in the establishment of the CRT. Electrolytic lesions of the POA, but not of the SCN, resulted in an increased amplitude of the CRT at both 24 degrees C and 6 degrees C, with the lower ambient temperature enhancing this amplitude change to a greater extent. These results suggest that the POA and the SCN are independently responsible for the homeostatic and circadian regulation of body temperature, respectively. The increased amplitude of the CRT after POA lesions raises the possibility that the thermoregulatory system may oppose rather than defend the circadian control of body temperature in normal animals, which is consistent with several recent behavioral findings.

Citations

Mar 20, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·R Refinetti
Sep 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Salvador Huitron-ResendizHoward S Fox
Jun 1, 1997·The Journal of Physiology·R Refinetti, M Menaker
Mar 15, 1997·Annals of the New York Academy of Sciences·R Refinetti
Jul 22, 2009·Ageing Research Reviews·Dietmar Weinert
Feb 9, 2011·The European Journal of Neuroscience·Laurent NexonSylvie Raison
May 7, 2014·Hormones and Behavior·Z Yan WangBrian J Prendergast
May 8, 1999·The American Journal of Physiology·E L Robinson, C A Fuller
Jun 16, 2001·Journal of Biological Rhythms·T J BartnessG E Demas
Dec 1, 2020·Temperature : Multidisciplinary Biomedical Journal·Roberto Refinetti

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