PMID: 15375440Sep 18, 2004Paper

Effects of hypothermia on ischaemic depolarisation in brain : a comparison of responses in rat and gerbil

Cryo Letters
Barry Fuller, Edward Proctor

Abstract

The latency of development of ischaemic depolarization (LID) has been used to compare the relative effects of different levels of hypothermia on ischaemic responses in brains of rat and gerbil, using a model with imposed complete cessation of cerebral blood flow (CBF=0). At temperatures reducing from 37 degrees C to 20 degrees C, the LIDs were consistently shorter in the gerbil than in the rat. For example, at 37 degrees C the LID in the gerbil was 0.71+/- 01.2 min, and in the rat, 1.37 +/- 0.02 min respectively (P<0.01), whilst at 20 degrees C, the values were 5.48 +/- 0.25 min and 7.30 +/- 0.76 min (P<0.01). However, the relative effects of hypothermia on each species were similar (by linear regression with slopes of -0.29 and -0.35 min/degree C in the two species). There may be underlying differences in brain biophysics or structure between species, but in spite of this, applied hypothermia still imposes a similar depression on the development of ischaemic damage. Both models may thus be used in studies of brain hypothermia as long as the intrinsic differences are appreciated.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.