Effects of hypoxia and acidosis on vascular plasminogen activator release in the pig ear perfusion system

Thrombosis Research
L TappyF Bachmann

Abstract

The influence of hypoxia and acidosis on the release of vascular plasminogen activator was studied in the isolated perfused pig ear. Perfusion with deoxygenated or acid solutions led to significant increases in plasminogen activator release (p less than 0.001); acid solutions of pH 6.7 were more effective than those of pH 6.9. Perfusions with lactate and AMP, two metabolic products which might act as mediators of fibrinolytic stimulation during hypoxia, resulted in moderate increases of plasminogen activator in the effluent (p less than 0.01).

References

Feb 1, 1976·Thrombosis Research·F Markwardt, H P Klöcking
Jul 1, 1978·Archives of Biochemistry and Biophysics·R Radcliffe, T Heinze
Oct 1, 1962·The American Journal of the Medical Sciences·R L CLARKE, E E CLIFFTON

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Citations

Jan 1, 1994·Annals of Hematology·D MenzelJ W ten Cate
Feb 15, 1987·Thrombosis Research·M StegnarJ P Chen
Apr 10, 2002·Acta Anaesthesiologica Scandinavica·B OsterlundB Biber
Jun 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Soheyla SaadiJeffey L Platt
May 29, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Stefan AcostaMartin Björck

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