Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice

Neurobiology of Disease
Natalia Rodriguez-AlvarezDavid C Henshall

Abstract

Seizures are common during the neonatal period, often due to hypoxic-ischemic encephalopathy and may contribute to acute brain injury and the subsequent development of cognitive deficits and childhood epilepsy. Here we explored short- and long-term consequences of neonatal hypoxia-induced seizures in 7 day old C57BL/6J mice. Seizure activity, molecular markers of hypoxia and histological injury were investigated acutely after hypoxia and response to chemoconvulsants and animal behaviour was explored at adulthood. Hypoxia was induced by exposing pups to 5% oxygen for 15 min (global hypoxia). Electrographically defined seizures with behavioral correlates occurred in 95% of these animals and seizures persisted for many minutes after restitution of normoxia. There was minimal morbidity or mortality. Pre- or post-hypoxia injection of phenobarbital (50mg/kg) had limited efficacy at suppressing seizures. The hippocampus from neonatal hypoxia-seizure mice displayed increased expression of vascular endothelial growth factor and the immediate early gene c-fos, minimal histological evidence of cell injury and activation of caspase-3 in scattered neurons. Behavioral analysis of mice five weeks after hypoxia-induced seizures detected novel ...Continue Reading

References

Jun 1, 1991·Annals of Neurology·F E JensenJ L Burchfiel
Nov 1, 1985·Physiology & Behavior·S L Moshé, B J Albala
Feb 1, 1981·Annals of Neurology·J E RiceJ B Brierley
Mar 1, 1993·Brain Research. Molecular Brain Research·F E JensenG D Mower
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·P E Schauwecker, O Steward
Aug 12, 1999·The New England Journal of Medicine·M J PainterJ Alvin
Dec 28, 1999·Brain Research. Developmental Brain Research·L HuangG L Holmes
Oct 6, 2000·The Journal of Clinical Investigation·G L Semenza
Aug 3, 2001·Neuroscience·B ClancyB L Finlay
Apr 2, 2002·Nature Genetics·Jianhua ZhangMing Xu
Sep 11, 2002·Trends in Neurosciences·Sarit Avishai-ElinerTallie Z Baram
Feb 26, 2003·European Journal of Pharmacology·Michel Bourin, Martine Hascoët
Mar 17, 2004·Trends in Pharmacological Sciences·John W OlneyChrysanthy Ikonomidou
Sep 24, 2004·Lancet Neurology·Sheryl R HautSolomon L Moshé
Oct 7, 2004·Pediatric Neurology·Anne M ComiMary Ann Wilson
Jun 9, 2005·Brain Research. Developmental Brain Research·Mohamad A MikatiMarwan El Sabban
Oct 18, 2005·Nature Medicine·Volodymyr I DzhalaKevin J Staley
Aug 9, 2007·Annals of Neurology·Faye S Silverstein, Frances E Jensen
Aug 24, 2007·Journal of Child Neurology·Raman Sankar, Jong M Rho
Oct 24, 2007·The Journal of Comparative Neurology·Shilpa D Kadam, F Edward Dudek
Dec 11, 2008·Annals of Neurology·Brian S StoneFrances J Northington
Apr 1, 2009·Annals of Neurology·Yogendrasinh H RaolEdward C Cooper
Jul 7, 2009·Nature Reviews. Neurology·Sanjay N Rakhade, Frances E Jensen
Dec 5, 2009·Cell Death and Differentiation·M D'AmelioF Cecconi
Oct 6, 2010·Journal of Child Neurology·Jennifer M KwonUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Apr 27, 2011·Annals of Neurology·Frances J NorthingtonLee J Martin
Aug 30, 2011·Neurobiology of Aging·Mathieu E WimmerTed Abel
Jun 20, 2012·The European Journal of Neuroscience·Kevin E ChapmanAmy Brooks-Kayal
Sep 4, 2012·Pediatrics in Review·Maria Gillam-Krakauer, Brian S Carter
Dec 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sanjay N RakhadeFrances E Jensen

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Citations

Jun 23, 2016·Epilepsy Currents·Alica M GoldmanUNKNOWN American Epilepsy Society (AES)/National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Benchmark Stewards
Jul 19, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Eckhart J BuchmannNiranjan Thomas
Jan 14, 2017·Neuropharmacology·Natalia Rodriguez-AlvarezDavid C Henshall
Dec 16, 2017·ASN Neuro·Michael Rudy, Margot Mayer-Proschel
Jul 10, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Baoying WangHuiyu Yang
May 24, 2017·Frontiers in Cellular Neuroscience·Lancelot J MillarZoltán Molnár
Jul 4, 2018·Scientific Reports·Sean M M QuinlanEva M Jimenez-Mateos
Dec 7, 2018·Current Neuropharmacology·Nicolás Toro-UrregoFrancisco Capani
Oct 2, 2019·Frontiers in Neurology·Aihua WangJinzhi Liu
Mar 3, 2020·Frontiers in Pharmacology·Bridgette D SempleTerence J O'Brien
Jul 18, 2019·Frontiers in Neurology·Dominik KobylarekWojciech Kozubski
Oct 28, 2020·International Journal of Molecular Sciences·Aida Menéndez MéndezTobias Engel
Dec 12, 2020·Cells·Aisling Leavy, Eva M Jimenez Mateos
May 21, 2021·Molecular and Cellular Neurosciences·Jocelyn J Lippman-BellFrances E Jensen
May 25, 2021·Frontiers in Pharmacology·Silvia Regina Bica KohekLuiz E Mello
Aug 8, 2021·Environmental Science and Pollution Research International·Hagar N Abd AllahEman S Abdel-Reheim
Aug 13, 2021·Stem Cell Reviews and Reports·Catherine BrégèreRaphael Guzman
Sep 28, 2021·Frontiers in Molecular Neuroscience·Edward BeamerTobias Engel

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