PMID: 10785612Apr 29, 2000Paper

Effects of hypoxia on regulation of prostanoid production in decidual endothelial cells in normal and preeclamptic pregnancy

Journal of the Society for Gynecologic Investigation
J RoweE D M Gallery


To examine the effect on prostacyclin and thromboxane production of incubating decidual endothelial cells under hypoxic conditions, comparing cells from normal and preeclamptic pregnancies. Furthermore, to determine whether hypoxia is deleterious to cell growth, and test the effects of stimulation and inhibition on prostanoid production. Decidual endothelial cells were exposed for a total of 40 hours to normoxic (20% O2) or hypoxic (2% O2) conditions. Prostacyclin and thromboxane secretion over the final 24 hours of incubation was measured and cell numbers after incubation determined. Lipopolysaccharide (LPS) (1.0 microgram/mL) was used as a stimulator and pirmagrel (1.0 mumol/L) and tranylcypromine (10.0 mumol/L) as prostanoid synthase inhibitors. Incubations in hypoxia resulted in increased thromboxane (P < .05) but no change in prostacyclin production. This thromboxane increase was abrogated by pirmagrel. LPS caused significant stimulation of prostacyclin and thromboxane secretion and both LPS and hypoxia resulted in lower cell numbers. Decidual endothelial cells from normal and preeclamptic pregnancies were generally not different. This study indicates that in preeclampsia, where decidual endothelial cells are in a relative...Continue Reading


Mar 18, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Helena C ParkingtonMarianne Tare
Dec 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Rachel J A HelliwellMurray D Mitchell
Jul 5, 2001·European Journal of Pharmacology·A J TrangM E Ward
Mar 19, 2004·Biology of Reproduction·S CampbellE D M Gallery
Aug 22, 2007·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Bei XuAnnemarie Hennessy
May 11, 2000·Obstetrical & Gynecological Survey·J R WaxC J Ingardia

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