PMID: 8590317Feb 1, 1995Paper

Effects of hypoxia on the antiproliferative activity of human interferons

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
A NaldiniV Bocci

Abstract

We studied the effects of pharmacologically attainable concentrations of interferon-alpha (IFN-alpha) and gamma (IFN-gamma) on the growth of cells incubated under hypoxic conditions (2% O2; approximately 14 mm Hg partial pressure) or exposed to oxygen at atmospheric pressure (21% O2; approximately 147 mm Hg). The cells were from four IFN-sensitive lines: A-549 lung carcinoma and G-361 human melanoma cells grow better under hypoxic conditions, but the growth of Hep-2 laryngeal carcinoma and WISH amnion cells is not affected by the environmental oxygen tension. The antiproliferative effects of the IFN were assessed in terms of cell cloning efficiency and also from the number of cells, relative to controls, measured 1, 2, and 3 days after seeding. Under hypoxic conditions, the cloning efficiency of A-549 and G-361 cells was increased, and they became significantly less responsive to the antiproliferative effect of IFN, and especially of IFN-gamma. No such effects were seen with WISH or Hep-2 cells. Hypoxic conditions are found in the necrotic areas present in most solid tumors, and our results suggest that these may decrease the antiproliferative effects of IFN. They may in part explain why IFNs have so little antitumor activity i...Continue Reading

References

Dec 1, 1978·Journal of Cellular Physiology·T R BradleyM Rosendaal
Jan 1, 1987·Cancer Metastasis Reviews·J E Moulder, S Rockwell
Dec 24, 1981·Nature·A A Branca, C Baglioni
May 1, 1984·British Journal of Cancer·V Gupta, R Eberle
Dec 1, 1984·Journal of Cellular Physiology·I W Taylor, P J Hodson
Apr 1, 1993·Journal of Interferon Research·A NaldiniV Bocci

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Citations

Jun 29, 2006·Biology of the Neonate·Saraid S BilliardsJonathan J Hirst
Dec 8, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A Larini, V Bocci

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