Effects of ICI 118.551, a selective beta-2 adrenergic blocking agent on the guinea pig cardiac excitability and ventricular fibrillation threshold

Acta Physiologica Hungarica
B CuparencuA Cuprian

Abstract

In isolated guinea pig perfused hearts ICI 118.551, a selective beta 2 adrenoceptor antagonist, induced transient ventricular extrasystoles. Following the termination of the perfusion, a very significant increase of both the ventricular fibrillation threshold and the refractory periods were measured. In guanethidine pretreated hearts, ICI 118.551 failed to induce premature beats. At the same time the fibrillation threshold and refractory periods exhibited a very significant decrease. The perfusion of equimolecular concentration of metoprolol, a beta-1-adrenoceptor antagonist, and (+) propranolol, a quinidine-like compound, induced, in most experimental settings, similar results as ICI 118.551. Thus, besides its beta-2-adrenoceptor antagonist properties, ICI 118.551 presented other pharmacological actions.

References

Sep 1, 1978·The Journal of Antimicrobial Chemotherapy·G W Houghton, R Templeton
Dec 1, 1988·International Journal of Radiation Oncology, Biology, Physics·H B Wolkov, M Bagshaw
May 1, 1983·Journal of Cardiovascular Pharmacology·A J BilskiJ L Wale

Related Concepts

ICI 118551, hydrochloride
Adrenergic beta-Antagonists
Cardiac Pacing, Artificial
Guanethidine Sulfate (2: 1), 14C-Labeled
Cavia porcellus
Cardiac Conduction System
Perfusion
Propanolamines
Vestin
Ventricular Fibrillation

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