Effects of ICRF-187 on the cardiac and renal toxicity of epirubicin in spontaneously hypertensive rats

Cancer Chemotherapy and Pharmacology
M DardirV J Ferrans

Abstract

A study was made of the protective effect of ICRF-187 against the cardiotoxicity and nephrotoxicity produced by epirubicin in spontaneously hypertensive rats (SHR). A total of 20 SHR were divided into 4 groups of 5 animals; the first group received i.v. injections of 1.5 mg/kg epirubicin; the second was treated with i.p. injections of 50 mg/kg ICRF-187 30 min before receiving 1.5 mg/kg epirubicin; the two remaining groups received ICRF-187 and saline, respectively, and served as controls. The experiment was terminated after 12 weekly injections (total cumulative dose of epirubicin, 18 mg/kg). Morphologic studies showed that severe cardiomyopathy manifested by myofibrillar loss and dilatation of the sarcoplasmic reticulum and nephropathy characterized by tubular dilatation and atrophy, protein casts in the lumina of renal tubules, and glomerular vacuolization occurred in SHR given epirubicin alone. Animals receiving the combination of ICRF-187 and epirubicin showed a marked reduction in the severity of cardiomyopathy and a moderate reduction in nephropathy. These changes, and their modification by ICRF-187, were similar to those we have previously observed in SHR treated with total cumulative doses of 12 mg/kg doxorubicin. Such ...Continue Reading

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Citations

Jan 1, 1992·Cancer Chemotherapy and Pharmacology·C AgenM Del Tacca
Mar 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M M al-Harbi
Aug 20, 2009·Cardiology in Review·Kuldeep Maradia, Maya Guglin
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May 1, 1991·Hypertension·M Martinez-Maldonado

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