Effects of iloperidone, combined with desipramine, on alcohol drinking in the Syrian golden hamster

Neuropharmacology
Jibran Y Khokhar, Alan I Green

Abstract

Alcohol use disorder in patients with schizophrenia dramatically worsens their clinical course, and few treatment options are available. Clozapine appears to reduce alcohol use in these patients, but its toxicity limits its use. To create a safer clozapine-like drug, we tested whether the antipsychotic iloperidone, a drug that combines a weak dopamine D2 receptor blockade and a potent norepinephrine alpha-2 receptor blockade would reduce alcohol drinking, and whether its effect on alcohol drinking could be increased if combined with an agent to facilitate norepinephrine activity. Syrian golden hamsters (useful animal model for screening drugs that reduce alcohol drinking in patients with schizophrenia) were given free access to water and alcohol (15% v/v) until stable drinking was established. Animals (n = 6-7/group), matched according to alcohol intake, were treated daily with each drug (iloperidone; clozapine; haloperidol; desipramine [norepinephrine reuptake inhibitor]; with idazoxan [norepinephrine alpha-2 receptor antagonist]) or with a two-drug (iloperidone + desipramine; iloperidone + idazoxan) combination for 14 days. Moderate doses of iloperidone (1-5 mg/kg) significantly reduced alcohol drinking (p < 0.05) in the hams...Continue Reading

References

Oct 1, 1979·Pharmacology, Biochemistry, and Behavior·P J Kulkosky, N W Cornell
Mar 1, 1979·Pharmacology, Biochemistry, and Behavior·R A HarrisJ Case
Jan 1, 1991·Schizophrenia Bulletin·S J BartelsD H Freeman
Nov 21, 1990·JAMA : the Journal of the American Medical Association·D A RegierF K Goodwin
Oct 1, 1987·Acta Psychiatrica Scandinavica·P AllebeckB Wistedt
May 1, 1993·Pharmacology, Biochemistry, and Behavior·R CorbettR W Dunn
May 1, 1996·Schizophrenia Research·S GuptaE A Haffke
Aug 1, 1996·Psychiatric Services : a Journal of the American Psychiatric Association·R R OwenB J Cuffel
Nov 5, 1997·The Psychiatric Clinics of North America·J M Harkavy-Friedman, E Nelson
May 18, 2000·Biochemical and Biophysical Research Communications·W M KeungO Lazo
Dec 31, 2002·Schizophrenia Research·Alan I GreenRael D Strous
Feb 20, 2003·European Journal of Pharmacology·Hans O Kalkman, Erika Loetscher
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Uriel Heresco-Levy
May 12, 2004·Chemico-biological Interactions·Katalin MonostoryLászló Vereczkey
Sep 10, 2004·Current Psychiatry Reports·David T ChauAlan I Green
Sep 29, 2004·Psychiatry Research·Alan I GreenJoseph J Schildkraut
Apr 29, 2005·The International Journal of Neuropsychopharmacology·Monica M MarcusTorgny H Svensson
Jun 19, 2007·Journal of Substance Abuse Treatment·Alan I GreenChristopher O'Keefe
Nov 10, 2009·Neuropharmacology·David T ChauAlan I Green
May 14, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Monica M MarcusTorgny H Svensson
Mar 1, 2007·Journal of Dual Diagnosis·R Andrew Chambers
Dec 21, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ipek Komsuoglu CelikyurtTayfun I Uzbay
Mar 25, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emmanuelle Simon O'BrienMickaël Naassila
Oct 25, 2011·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Tayfun I Uzbay
Sep 8, 2015·Journal of Psychiatric Research·David T ChauAlan I Green

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