Abstract
Iminodipropionitrile (IDPN), a compound that causes dyskinetic symptoms in animals and has possible use as a model for human dyskinesia, was tested in mice and rats for its effect on cerebral amino acids. In mice, 2 h after IDPN administration, the level of total brain alanine was reduced; after 5 h the levels of aspartic acid and glutamic acid were also reduced, and the level of glutamine was increased. In rats, after chronic administration of IDPN, the level of glutamic acid in the total brain tissue was reduced. After acute administration of IDPN using microdialysis, extracellular GABA and extracellular glutamine levels in the striatum were elevated. This study shows that IDPN causes alterations in total and extracellular levels of neurotransmitter amino acids in the brain, which could have a role in IDPN-induced dyskinesia.
References
Mar 1, 1992·Neurochemical Research·E TothA Lajtha
Jan 1, 1990·Archives of Toxicology·H TaniiK Hashimoto
Jul 26, 1988·Brain Research·J L CadetS Fahn
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·J L Cadet
Apr 10, 1989·Brain Research·J L CadetE London
Aug 1, 1989·Analytical Biochemistry·A NeidleD S Dunlop
Dec 1, 1986·Neuroscience·R RomoJ Glowinski
Dec 29, 1987·Brain Research·J L CadetE B De Souza
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Apr 1, 1985·Neuropharmacology·A MetzA R Green
Jan 1, 1968·International Journal of Neuropharmacology·J K TewsW E Stone
Dec 1, 1966·Journal of Neurochemistry·F VivancoC Jimenez-Diaz
Jan 1, 1983·Advances in Neurology·S Fahn
Dec 1, 1984·Neuropharmacology·A R Green
Jun 1, 1984·Experimental Neurology·J S Schneider
Jan 1, 1980·Neuroscience·L A LeeP Slater
Jan 5, 1995·Regulatory Peptides·Y KawadaA Mori
Jan 1, 1995·Brain Research Bulletin·M TariqM Arshaduddin
Mar 5, 1993·Brain Research·F FornaiG U Corsini
Aug 1, 1993·Neuropharmacology·E TothA Lajtha
Mar 1, 1993·Neurotoxicology and Teratology·K M CroftonM E Stanton
Citations
Apr 24, 1999·Journal of Applied Toxicology : JAT·M TariqS A Deeb
Mar 31, 1999·Neurochemistry International·E TóthA Lajtha
Feb 13, 2016·Neurochemical Research·Xiaona WangPeng Sun
Oct 2, 2017·Neurotoxicity Research·Tomohiro OhgomoriShozo Jinno