Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats

Pharmacology, Biochemistry, and Behavior
Yoshihisa KitamuraYutaka Gomita

Abstract

We examined the influence of imipramine and lithium on wet-dog shakes induced by the (+/-)-DOI, 5-HT2A receptor agonist in adrenocorticotropic hormone (ACTH)-treated rats. The administration of imipramine for 14 days decreased the (+/-)-DOI-induced wet-dog shakes response; chronic administration of lithium for 14 days, however, had no effect. Chronic ACTH (100 microg/rat sc) treatment increased the wet-dog shake response induced by (+/-)-DOI. This effect of ACTH for 14 days, increasing the (+/-)-DOI-induced wet-dog shakes, was not inhibited by a 14-day administration of imipramine. Chronic coadministration of imipramine and lithium, lasting 14 days, decreased the wet-dog shakes response induced by (+/-)-DOI in rats treated with ACTH for 14 days. These findings indicate that lithium inhibits the hyperfunction of the 5-HT2A receptor in rats treated with ACTH when coadministered with imipramine.

References

Sep 1, 1976·Archives of General Psychiatry· CarrollJ Mendels
Apr 29, 1986·European Journal of Pharmacology·R C Arora, H Y Meltzer
Jan 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·J E ChristieG Fink
Mar 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·C Dé MontignyJ P Deschenes
Jul 1, 1995·Brain Research. Molecular Brain Research·S J Garlow, R D Ciaranello
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Yoshihisa KitamuraYutaka Gomita

❮ Previous
Next ❯

Citations

Nov 26, 2003·European Journal of Pharmacology·Yoshihisa KitamuraYoshiro Tanizaki
May 17, 2005·Pharmacology, Biochemistry, and Behavior·Yasuhiro KawakamiYutaka Gomita
Apr 4, 2008·Human Molecular Genetics·Andrea M AllanXinyu Zhao
Apr 6, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Bingjin LiHiroaki Araki
Jul 2, 2002·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yoshihisa KitamuraYutaka Gomita
Jun 2, 2015·Biological & Pharmaceutical Bulletin·Ryuki TsutsuiChiaki Kamei
Feb 26, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Gerard J Marek
Aug 8, 2013·Journal of Biochemical and Molecular Toxicology·Bingjin LiRanji Cui
Apr 26, 2013·Journal of Pharmacological Sciences·Keiko KuwatsukaToshiaki Sendo
Dec 7, 2005·European Journal of Pharmacology·Bingjin LiHiroaki Araki
Nov 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mireille BasselinStanley I Rapoport
Apr 21, 2006·Basic & Clinical Pharmacology & Toxicology·Sameer A OtoomReginald P Sequeira
Apr 19, 2017·CNS Neuroscience & Therapeutics·Sarah DelcourteNasser Haddjeri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.