Effects of imipramine and sertraline on protein kinase activity in rat frontal cortex

European Journal of Pharmacology
C TadokoroK Kamijima

Abstract

Three-week administration of sertraline or imipramine to rats (10 mg/kg, intraperitoneally, twice a day) increased ex vivo cyclic AMP-dependent protein kinase activity in the soluble but not in the particulate fraction of the frontal cortex. However, cyclic AMP-dependent protein kinase activity was not affected in either fraction of the parietotemporal cortex and hippocampus. Neither antidepressant altered protein kinase C activity in the soluble and particulate fractions or Ca2+/calmodulin-dependent protein kinase II activity in the frontal cortex. Therefore, sertraline and imipramine both selectively enhance cyclic AMP-dependent protein kinase activity in the frontal cortex. This enhancement might be involved in their biochemical mechanisms.

References

Aug 1, 1996·The American Journal of Psychiatry·R C SheltonF Sulser

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Citations

Sep 1, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M SalaP Brambilla
Jun 16, 2005·Neurochemistry International·Magdolna PákáskiJános Kálmán
Jul 13, 1999·British Journal of Pharmacology·A BenelliS Genedani
Aug 16, 2002·Bipolar Disorders·Maurizio PopoliGiorgio Racagni
Jul 20, 2002·Journal of Affective Disorders·Shigeru Morishita, Shozo Aoki
Nov 24, 2011·Neurochemistry International·Ping ChenMeng-Yang Zhu
Mar 5, 2011·Basic & Clinical Pharmacology & Toxicology·Jong-Khing HuangChung-Ren Jan
Aug 31, 2012·Drug and Chemical Toxicology·Ko-Long LinChung-Ren Jan
Nov 4, 2009·Journal of Receptor and Signal Transduction Research·Chun-Jen HuangChung-Ren Jan
Aug 22, 2003·Molecular Psychiatry·A MorettiR F Villa
Jul 27, 1999·British Journal of Clinical Pharmacology·J M VilaS Lluch
Jan 21, 2011·Human & Experimental Toxicology·Jau-Min ChienChung-Ren Jan

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